Drugs that target mitotic spindle proteins have been proven useful for tackling tumor growth. Eg5, a kinesin-5 family member, represents a potential target, since its inhibition leads to prolonged mitotic arrest through the activation of the mitotic checkpoint and apoptotic cell death. Monastrol, a specific dihydropyrimidine inhibitor of Eg5, shows stereo-specificity, since predominantly the (S...

Citalopram is marketed as a racemate (50:50) mixture of the S(+)-enantiomer and R(-)-enantiomer and the active S(+)-enantiomer (escitalopram) that possess inhibitory effects. Citalopram was introduced in Sweden in 1992 and is the most frequently used antidepressant to date in Sweden. In 2002, escitalopram was introduced onto the Swedish market for treatment of depression and anxiety disorders. ...

We address the purification of target enantiomer a chiral compound from its racemic mixture, through simulated moving bed (SMB) chromatography either as standalone or combined with recycle and racemization undesired enantiomer. carry out comparative assessment two processes focus on role kinetics, effect selectivity stationary phase, upstream symmetric synthesis racemate. The analysis is genera...

A reversed phase enantioselective high performance liquid chromatographic method was developed and validated for determination ofS-enantiomer in Cinacalcet drug substance. The enantiomers of Cinacalcet were resolved on a Chiralcel-OJH (250mmx4.6mm, 5microns) column using a mobile phase system containing n-Hexane, ethanol and n-butyl amine (90:10:1). The resolution between enantiomers was found ...

[Ru(phen)2(dppz)]2+ has been studied since the 1990s due to its 'light-switch' properties. It can be used as a luminescent DNA probe, with emission switched on through DNA binding. The luminescence observed is dependent on the solvent accessibility of the pyrazine nitrogen atoms, and therefore is sensitive to changes in both binding site of the cation and chromophore orientation. The compound i...

We report a theoretical study of the first silver-dependent enantiodivergent gold-catalysed reaction. The combination single chiral binuclear gold(I) chloride complex and silver perchlorate catalyses asymmetric intramolecular hydroamination alkenes affords both enantiomers products by applying simple solvent change from toluene to methanol. A gold-silver adduct that occurs only in methanol appe...

The reactions with DNA and mutagenic activities toward Salmonella typhimurium TA 100 of the R,S,S,R and S,R,R,S enantiomers of anti-1,2,-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (anti-5-MeC-1,2-diol-3,4-epoxide), anti-5-MeC-7,8-diol-9,10-epoxide, and anti-6-MeC-1,2-diol-3,4-epoxide were compared because among these compounds only the R,S,S,R enantiomer of anti-5-MeC-1,2-diol-3,4-...

A simple and rapid chiral liquid chromatographic method was developed for the enantiomeric separation of Sertraline hydrochloride (cis-(1S, 4S)-4-(3, 4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride) and its undesired cis-enantiomer (cis(1R, 4R)-4-(3, 4-dichlorophenyl)-N-methyl-1,2,3,4tetrahydronaphthalen-1-amine hydrochloride). Superior resolution between Sertralin...