Background: Endometrial carcinoma is the most common malignancy in the female genital tract and associated with considerable degree of morbidity. Endometrial carcinoma has traditionally been divided into type I and type II cancers. Type I tumors are low grade endometrioid carcinoma that frequently arise in a setting of excess estrogen and associated with good clinical outcome while type II are ...

High-risk type II endometrial cancers account for ~30% of cases but ~75% of deaths due, in part, to their tendency to metastasize. Histopathological studies of type II endometrial cancers (non-endometrioid, mostly serous) suggest overproduction of activin B and down-regulation of E-cadherin, both of which are associated with reduced survival. Our previous studies have shown that activin B incre...

background endometrial carcinoma is a highly prevalent gynecologic malignancy. the international federation of gynecology and obstetrics (figo) staging system underwent significant revision on 2009. key changes in the figo staging system include simplification of stage i endometrial cancer and removal of cervical mucosal invasion as a separate stage. mri is a noninvasive diagnostic method for p...

p21-activated kinases (Paks) are serine/threonine protein kinases involved in biological events linked to malignant tumor progression. In this study, expression of Pak1, p-Pak2 Ser20, Pak4, pPak4 Ser474 in 21 normal endometrium, 16 hyperplastic endometrium without atypia, 17 atypical complex hyperplasia and 67 endometrial cancers was assessed by immunohistochemistry and correlated with clinicop...

In order to assess the efficacy of hysteroscopic endometrial ablation and factors which are important in it's success, a prospective, randomized study was performed in Shiraz university hospitals between Sep. 1995 to Feb. 1998. 50 patients with chief complaints of menorrhagia that were in reproductive age (25- 50 years) and had shown no response to medication and D&C underwent endometrial ...

OBJECTIVE To determine the frequencies of histopathological findings in endometrial and endocervical biopsy samples with clinical history of Postmenopausal Bleeding (PMB). STUDY DESIGN Descriptive cross-sectional study. PLACE AND DURATION OF STUDY Section of Histopathology, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from February 2012 to Janu...

Endometrial carcinoma is one of the commonest Gynecological malignancy. Endometrioid type most common associated with hyper-estrogenic state and has better prognosis. While non endometrioid less common, elderly age dismal Uterine cancer often observed in higher group average at diagnosis 60 years. It occurs women over 50. 16 cases endometrial were collected from January 2018 until November 2020...

RATIONALE Endometrial stromal sarcoma (ESS) is rare, representing only approximately 0.2% of all uterine malignancies. Mixed type endometrial carcinomas (MT-ECs) are rare tumors with both type I and II features, and are difficult to diagnose. Cases of ESS and MT-ECs coexisting in the same patient are extremely rare. This study aimed to describe a case of ESS in combination with MT-ECs in a 47-y...

CONTEXT AND OBJECTIVE The Wnt pathway is involved in tumorigenesis of several tissues. For this reason, we proposed to evaluate Wnt gene expression in endometrial cancer type I. DESIGN AND SETTING Cross-sectional study on materials gathered from the tissue bank of the Department of Pathology, Universidade Federal de São Paulo. METHODS Endometrial specimens were obtained from surgeries perfo...

Endometrial cancer arises from the uterine body and fundus in many cases, but can also originate from the lower region of the uterine body through the upper region of the cervix. Such tumors are referred to as carcinoma of the lower uterine segment (LUS) or isthmus, and account for 3-6.3% of all cases of endometrial cancer. This relatively low incidence has permitted performance of only small-s...