BACKGROUND In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and pathology, the origin of neovasculature in xenografts remains controversial. The aim of this study was to assess the origin of the neovasculature of endometrial grafts in different mouse models. ...

Angiogenesis is a key step in the initiation and progression of an invasive breast cancer. High microvessel density by morphological characterization predicts metastasis poor survival women with cancers. However, morphologic subject to variability only can evaluate limited portion Consequently, Magnetic Resonance Imaging (MRI) currently being evaluated assess vascularity. Recently, through new ...

During the course of experiments examining the immunobiology of corneal transplants, the corneas of athymic, nude mice (nu/nu) were found to contain blood vessels that extended through the entire superficial stroma into the centermost portion of the cornea. The presence of corneal vessels was not related to the immunodeficient condition of the nude mouse since corneas from the severe combined i...

The dissolving microneedle loading vasodilatorTOP-M119 (M119) penetrates the scalp and releases drug to blood vessels. TheM119 induces vasodilation angiogenesis, it causes vascularization around hair follicles supplying oxygen nutrients. This mode of action M119 finally affects alopecia follicles' conversion anagen growth. is reported by Hyungil Jung co-workers in article number 2200052.

Endometrial cancer is the most common gynecological in developed countries, second poor countries and developing after cervical cancer. Most endometrial patients come with complaints of bleeding at an early stage. It’s important to make right diagnosis determine appropriate treatment. Treatment depends on stage determined by surgery. After surgery, patient’s risk was classified as low, moderate...

Guidance molecules have attracted interest by demonstration that they regulate patterning of the blood vascular system during development. However, their significance during postnatal angiogenesis has remained unknown. Here, we demonstrate that endothelial cells of human malignant brain tumors also express guidance molecules, such as EphB4 and its ligand ephrinB2. To study their function, EphB4...

High numbers of adult stem cells are still required to improve the formation of new vessels in scaffolds to accelerate dermal regeneration. Recent data indicate a benefit for vascularization capacity by stimulating stem cells with lipopolysaccharide (LPS). In this study, stem cells derived from human skin (SDSC) were activated with LPS and seeded in a commercially available dermal substitute to...

PURPOSE To correlate morphologic changes in the retinal vasculature with degenerative changes in the neuronal retina of mice lacking 56 amino acids from the N-terminus of the Norrie disease (ND) gene product. METHODS Posterior eye segments of ND mice of different age groups were investigated by light and electron microscopy (EM) and scanning EM of vascular corrosion cast preparations. The res...

The human endometrium is a complex tissue comprised of different cell types, including epithelial, stromal, inflammatory, perivascular, and blood vessel cells. The hormonal receptivity and distribution of these cell populations change during the menstrual cycle. Cyclical endometrial growth is dependent on its ability to regenerate a vascular capillary network, which grows in parallel with the p...