accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. nadph oxidase has been recognized as a major source of oxidative stress in vasculature. however, the relation between nadph oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. the present study aimed to investigate the rele...

OBJECTIVE AND METHODS To review, from the clinical perspective, the contribution of dysfunction of the vascular endothelium to the pathogenesis of diabetic micro- and macroangiopathy. RESULTS Available data indicate that endothelial dysfunction in diabetes complicated by micro- or macroalbuminuria (renal microangiopathy) is generalised. The close linkage between microalbuminuria and endotheli...

Key Points • The endothelium is a key participant in the homeostasis of the vessel wall. • Nitric oxide (NO) plays a key role in regulating healthy vascular function. • Reduced local NO bioavailability is a characteristic hallmark of vascular endothelial dysfunction. • Endothelial dysfunction is chiefly driven by oxidative stress and inflammation. • A number of techniques for assessing endothel...