Drug solubility is one of the most significant physicochemical properties as it related to drug design, formulation, quantification, recrystallization, and other processes, so understanding crucial for pharmaceutical industry. In this context, research presents thermodynamic analysis sulfadiazine (SD) in cosolvent mixtures {acetonitrile + 1-propanol} at 9 temperatures (278.15 K–318.15 K), which...

The interaction of guest molecules ranging from pentan-1-ol to octan-1-ol with α-cyclodextrin (α-CD) in water of has been studied calorimetrically at 283.15, 288.15, 293.15, 298.15 and 308.15 K with an isoperibolic titration calorimeter designed in our laboratory. The calorimetric method employed allows the determination of the thermodynamic parameters characterizing the binding process, ∆G°m, ...

The complexation reaction between 1,13-bis(8-quinolyl)-1,4,7,10,13-pentaoxatridecane (Kryptofix5) ligand with Zn2+, Ni2+, Co2+, Pb2+, Mn2+ and Cu2+ ions were studied conductometrically in different AcetoNitrile-NitroMethane (AN-NM) and AcetoNitrile-Methanol (AN-MeOH) mixtures. The formation constants of the resulting...

Abstract Equilibrium solubility of triclocarban (TCC) expressed in mole fraction 1,4-dioxane and cyclohexane, as well, 19 {cyclohexane (1) + (2)} mixtures, was determined at seven temperatures from T = (288.15 to 318.15) K. Logarithmic TCC these cosolvent mixtures adequately correlated with a lineal bivariate equation function both the composition temperature. Apparent thermodynamic quantities ...

N6-Methyladenosine (m6A) is the most frequent modification in eukaryotic messenger RNA (mRNA) and its cellular processing functions are regulated by reader proteins YTHDCs YTHDFs. However, mechanism of m6A recognition still elusive. Here, we investigate this process combining atomistic simulations, site-directed mutagenesis, biophysical experiments using YTHDC1 as a model. We find that N6 methy...

Configuration transitions of individual molecules and atoms on surfaces are traditionally described using an Arrhenius equation with energy barrier and pre-exponential factor (attempt rate) parameters. Characteristic parameters can vary even for identical systems, and pre-exponential factors sometimes differ by orders of magnitude. Using low-temperature scanning tunnelling microscopy (STM) to m...