System engineering is one of the most powerful tools for comprehensive project management and control. This tool emphasized the life cycle of the projects, manages every single activity and helps manage the main elements of the project through a set of management and engineering processes. The goal of the current study is to use a system engineering approach in design phase in order or to meet ...

This research tends to development of the requirements elicitation methodology with regard to operational nature and hierarchical analysis for complex systems and also, regarding available technologies. This methodology applies Analytic Hierarchy Process (AHP) and Analytic Network Process (ANP) to ensure traceability of planned qualitative and quantitative data from requirements to available te...

Emilia sonchifolia (L.) DC (Compositae), an herbaceous plant found in Taiwan and India, is used as folk medicine. The clinical applications include inflammation, rheumatism, cough, cuts fever, dysentery, analgesic, and antibacteria. The activities of Emilia sonchifolia extract (ESE) on colorectal cancer cell death have not been fully investigated. The purpose of this study explored the inductio...

ESE-1/Elf3 and HER2 appear to establish a positive feedback regulatory loop, but the precise role of ESE-1 in HER2+ breast tumorigenesis remains unknown. Analyzing public repositories, we found that luminal B and HER2 subtype patients with high ESE-1 mRNA levels displayed worse relapse free survival. We stably knocked down ESE-1 in HER2+ luminal B BT474 cells and HER2 subtype SKBR3 cells, which...

The Evaluation Self-Efficacy (ESE) scale was designed as an outcome measure for evaluation research courses in social work. A revised version of the Social Cognitive Theory–based ESE (ESE-II) was developed and evaluated in the current study including both new and revised items. The ESE-II was evaluated in a final sample of 168 masters level students using a pretest–posttest design. Exploratory ...

Background: ETS factors comprise a large transcription factor family known to play a significant role in cellular development, differentiation, and transformation. The human Epithelial Specific Ets factor-1, ESE-1, is particularly relevant in breast cancer. Specifically, increased mRNA expression of ESE-1 and the Her2/neu protooncogene are correlated in breast cancer, and activation of the Her2...

Angiogenesis is a critical component of the inflammatory response associated with a number of conditions. Angiopoietin-1 (Ang-1) is an angiogenic growth factor that promotes the chemotaxis of endothelial cells and facilitates the maturation of new blood vessels. Ang-1 expression is up-regulated in response to tumor necrosis factor-alpha (TNF-alpha). To begin to elucidate the underlying molecula...

The systems engineering process often begins somewhere in the middle of a project. Naturally, the systems engineering process should be different for a project where systems engineering starts in the middle versus a project where it starts at the beginning of the project. This article presents a consensus of senior systems engineers and project managers at the Idaho National Engineering and Env...