Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. Several indole imidazole derivatives inhibit the catalytic activity rabbit substrate-specific manne...

adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of atp to camp. the inhibition of adenylyl cyclase was carried out by measuring the ability of the macrophage chemotactic protein-1 to inhibit the torskolin-induced enzyme activity. adenylyl cyclase activity in the presenc of macrophage chemotactic protein-1 was decreased compared to that in controls [2.11+/-0.15 (mean +/...

Inhibition of Aldose Reductase (AR) is very important in terms preventing many diabetic complications such as retinopathy, neuropathy, and cataract. In this study, inhibition effects some antiproliferative agents, which have been shown to biological activities besides their anticancer properties, on the AR enzyme, a diabetes-related were investigated. Biochanin A compound with an IC50 value 4.4...

Enzyme is a protein molecule acting as catalyst in enzyme reaction. Enzyme inhibition is a science of enzyme-substrate reaction influenced by the presence of any organic chemical or inorganic metal or biosynthetic compound due to their covalent or non-covalent interactions with enzyme active site. It is well known that all these inhibitors follow same rule to interplay in enzyme reaction. Prese...