PURPOSE To compare maternal and fetal effects of intravenous phenylephrine and ephedrine administration during spinal anesthesia for cesarean delivery in high-risk pregnancies. SOURCE An extensive literature search was conducted using the US National Library of Medicine, MEDLINE search engine, Cochrane review, and Google Scholar using search terms "ephedrine and phenylephrine," "preterm and t...

Ephedrine and phenylephrine are used to treat hypotension during combined general and epidural anesthesia, and they may change anesthetic depth. In the current study, we evaluated the effects of ephedrine versus phenylephrine on bispectral index (BIS) during combined general and epidural anesthesia. After injection of ropivacaine through the epidural catheter, general anesthesia was induced wit...

OBJECTIVE The aim of this randomized, double-blind, placebo-controlled study was to evaluate the effect of ephedrine pretreatment on the intensity of rocuronium injection pain when rocuronium was applied by timing principle and also to compare this effect with lidocaine and placebo. SUBJECTS AND METHODS 120 American Society of Anesthesiology risk score I-II patients scheduled for elective sur...

BACKGROUND How phenylephrine and ephedrine treatments affect global and regional haemodynamics is of major clinical relevance. Cerebral tissue oxygen saturation (Sct(O2) )-guided management may improve postoperative outcome. The physiological variables responsible for Sct(O2) changes induced by phenylephrine and ephedrine bolus treatment in anaesthetized patients need to be defined. METHODS A...

BACKGROUND AND AIMS While ephedrine was the preferred drug for treating spinal-induced hypotension in pregnancy, its use has declined because of resultant fetal acidosis. The objective of this randomized control trial was to compare the effects of a slow and rapid bolus of ephedrine on fetal acidosis, maternal blood pressure, and heart rate (HR) during cesarean section performed under spinal an...

INTRODUCTION Hypotensive episodes are a common complication of spinal anesthesia during Cesarean section. The purpose of this study was to compare the effectiveness and the side effects of vasopressors, ephedrine and phenylephrine, administered for hypotension during elective Cesarean section under spinal anesthesia. MATERIAL AND METHODS The study consisted of 100 selected ASA I/II females sc...

Background: Regional anaesthesia has become the preferred technique for caesarean section because general anaesthesia is associated with higher incidence of maternal morbidity and mortality. Ephedrine is the drug of choice to treat spinal-induced hypotension in caesarean patients, but a clinically relevant positive effect on neonatal outcome were not observed in some studies done in the past. S...

Dietary supplements containing ephedrine and other alkaloids related to ephedrine are largely consumed in various countries, with the purpose of energetic stimulation and weight loss. Despite the fact that it is not approved for marketing in Brazil, these products may be freely purchased over the Internet or at gyms/fitness centers. We report the case of a young athlete with no risk factors for...

The value of ephedrine as a therapeutic agent has been appreciated for some years but little attention has been paid to its dextrorotatory isomer pseudo-ephedrine. This latter alkaloid occurs in large quantities in the Indian species of ephedra, most of the specimens containing a proportion of 50 per cent, of the total alkaloid content. Lieut.-Col. R. N. Chopra, i-M.s., and his collaborators of...