نتایج جستجو برای: epithelial barriers

تعداد نتایج: 229269  

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Andrew B Maksymowych Lance L Simpson

Experiments were done to help localize the minimum essential domain within the botulinum toxin molecule that is necessary for binding and transport across human gut epithelial cells. The data demonstrated that the neurotoxin alone, in the absence of auxiliary proteins, undergoes transcytosis. The neurotoxin by itself was examined in the single chain (unnicked serotype B) and dichain (nicked ser...

Journal: :Journal of virology 2011
Li Lu Senthilkumar Palaniyandi Rongyu Zeng Yu Bai Xindong Liu Yunsheng Wang C David Pauza Derry C Roopenian Xiaoping Zhu

Strategies to prevent the sexual transmission of HIV include vaccines that elicit durable, protective mucosal immune responses. A key to effective mucosal immunity is the capacity for antigens administered locally to cross epithelial barriers. Given the role of neonatal Fc receptor (FcRn) in transferring IgG across polarized epithelial cells which line mucosal surfaces, FcRn might be useful for...

2017
Rocío López-Posadas Michael Stürzl Imke Atreya Markus F. Neurath Nathalie Britzen-Laurent

An essential role of the intestine is to build and maintain a barrier preventing the luminal gut microbiota from invading the host. This involves two coordinated physical and immunological barriers formed by single layers of intestinal epithelial and endothelial cells, which avoid the activation of local immune responses or the systemic dissemination of microbial agents, and preserve tissue hom...

2015
Ryo Shiomi Kenta Shigetomi Tetsuichiro Inai Masami Sakai Junichi Ikenouchi

Epithelial cells define the boundary between the outside and the inside of our body by constructing the diffusion barrier. Tight junctions (TJs) of epithelial cells function as barriers against invasion of harmful microorganisms into the human body and free diffusion of water or ions from the body. Therefore, formation of TJs has to be strictly controlled in epithelial cells. However, the molec...

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