نتایج جستجو برای: erg11

تعداد نتایج: 172  

ژورنال: :دانشور پزشکی 0
احسان فرح بخش ehsan farahbakhsh school of medical sciences, tarbiat modares university, tehran, iran.گروه قارچ شناسی پزشکی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران محمد حسین یادگاری mohammad hossein yadegari school of medical sciences, tarbiat modares university, tehran, iran.گروه قارچ شناسی پزشکی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران معصومه رجبی بذل masoumeh rajabi bazl department of clinical biochemistry, faculty of medicine, shaheed beheshti medical university, tehran, iran.گروه بیوشیمی بالینی، دانشکده علوم پزشکی، دانشگاه علوم پزشکی شهید یهشتی، تهران، ایران مجتبی تقی زاده ارمکی mojtaba taghizadeh armaki school of medical sciences, tarbiat modares university, tehran, iran.گروه قارچ شناسی پزشکی، دانشکده علوم پزشکی، دانشگاه تربیت مدرس، تهران، ایران فرزاد کتیرائی farzad katiraee faculty of veterinary medicine, university of tehran, tehran, iran.مرکز تحقیقات قارچ شناسی، دانشکده دامپزشکی، دانشگاه تهران، ایران

مقدمه و هدف: امروزه قارچ های فرصت طلب به ویژه قارچ کاندیدا آلبیکنس ازجمله شایع ترین عوامل مخاطره انگیز در بیماران نقص سیستم ایمنی هستند. افزایش روز افزون سویه های کاندیدا آلبیکنس مقاوم به داروهای آزولی مشکل اصلی بیماران مبتلا به ایدز است. هدف از این مطالعه، بررسی ژن erg11 در سویه های کاندیدا آلبیکنس مقاوم به فلوکونازول در بیماران آلوده به hiv مبتلا به کاندیدیازیس دهانی حلقی به روش واکنش زنجیره ...

Journal: :Genetics 2016
Yong-Jie Xu Amanpreet Singh Gerald M Alter

Hydroxyurea (HU) has been used for the treatment of multiple diseases, such as cancer. The therapeutic effect is generally believed to be due to the suppression of ribonucleotide reductase (RNR), which slows DNA polymerase movement at replication forks and induces an S phase cell cycle arrest in proliferating cells. Although aberrant mitosis and DNA damage generated at collapsed forks are the l...

Journal: :The Journal of antimicrobial chemotherapy 2012
Florent Morio Fabrice Pagniez Claire Lacroix Michel Miegeville Patrice Le Pape

OBJECTIVES To determine the mechanisms responsible for fluconazole resistance in two Candida albicans isolates (CAAL2 and CAAL76) recovered from two hospitalized patients after fluconazole prophylaxis. METHODS MICs of fluconazole and voriconazole were determined by the broth microdilution method (CLSI M27-A3), and by Etest(®) for amphotericin B. RNA expression levels of CDR1, MDR1 and ERG11 w...

Journal: :Nucleic acids research 2016
Daniel Capurso Henrik Bengtsson Mark R Segal

The spatial organization of the genome influences cellular function, notably gene regulation. Recent studies have assessed the three-dimensional (3D) co-localization of functional annotations (e.g. centromeres, long terminal repeats) using 3D genome reconstructions from Hi-C (genome-wide chromosome conformation capture) data; however, corresponding assessments for continuous functional genomic ...

Journal: :Antimicrobial agents and chemotherapy 1998
K A Marr C N Lyons T R Rustad R A Bowden T C White

Fluconazole-resistant Candida albicans, a cause of recurrent oropharyngeal candidiasis in patients with human immunodeficiency virus infection, has recently emerged as a cause of candidiasis in patients receiving cancer chemotherapy and marrow transplantation (MT). In this study, we performed detailed molecular analyses of a series of C. albicans isolates from an MT patient who developed dissem...

Journal: :PLoS Pathogens 2007
Wenqi Hu Susan Sillaots Sebastien Lemieux John Davison Sarah Kauffman Anouk Breton Annie Linteau Chunlin Xin Joel Bowman Jeff Becker Bo Jiang Terry Roemer

Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in humans, causing severe and often fatal invasive infections in immunocompromised patients. Currently available antifungal drugs to treat invasive aspergillosis have limited modes of action, and few are safe and effective. To identify and prioritize antifungal drug targets, we have developed a conditional promoter...

Journal: :Medical mycology 2005
Robert A Akins

Much progress has been made in the last decade in identifying genes responsible for antifungal resistance in Candida albicans. Attention has focused on five major C. albicans genes: ABC transporter genes CDR1 and CDR2, major facilitator efflux gene MDR1, and ergosterol biosynthesis genes ERG11 and ERG3. Resistance involves mutations in 14C-lanosterol demethylase, targeted by fluconazole (FLZ) a...

Journal: :Medical mycology 2011
L Alcazar-Fuoli E Mellado M Cuenca-Estrella D Sanglard

Azole-resistant strains of Aspergillus fumigatus have been detected and the underlying molecular mechanisms of resistance characterized. Point mutations in the cyp51A gene have been proved to be related to azole resistance in A. fumigatus clinical strains and with different resistance profiles depending on the amino acid change (G54E, G54V, G54R, G54W, M220V, M220K, M220T, M220I). The aim of th...

ژورنال: Iranian Biomedical Journal 2017
Ghajari, Ali, Kordbacheh, Parivash , Lotfali, Ensieh , Mirhendi, Hossein, Mohammadi, Rasoul, Noorbakhsh, Fatemeh, Rezaie, Sassan, Zaini, Farideh,

Background: Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms. Methods: The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined. The changes in the ...

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