Regional changes in striatal D2 dopamine (DA) receptor binding in castrated (CAST) or ovariectomized (OVX) rats were investigated following administration of a low dose of estradiol benzoate (EB), repeated treatment with EB followed by progesterone, or vehicle. In two separate experiments, there was a significant decrease in striatal D2 DA receptor binding in caudal striatum from OVX, but not C...

Our primary concern in this review is to give possible explanations and pose new questions on the phenomena concerning eff ects of neonatal estrogen exposure on the development and functions of reproductive organs and immune mechanisms particularly in male animals, in the light of new fi ndings and cencepts. At fi rst, our own experimental results on the pathological changes in the epididymis a...

The soybean phytoestrogen genistein has a range of estrogenic actions demonstrated in various species; however, only limited research has been done to investigate its effects in swine. The objective of this study was to characterize the effects of a graded dose of genistein on estrogen-sensitive uterine and cervical tissues in ovariectomized gilts. Thirty-four postpubertal gilts were ovariectom...

Most psychiatric disorders show a sex bias in incidence, symptomatology, and/or response to treatment. Males are more susceptible neurodevelopmental including autism spectrum disorder and attention-deficit activity disorder, while women prone major depressive anxiety after puberty. A striking difference between males females humans other mammals is that undergo process of brain masculinization ...

The activity of mitochondrial superoxide dismutase (MnSOD) and cytosol superoxide dismutase (CuZnSOD) was measured in corresponding subcellular fractions prepared from the thymi of intact and chronically gonadectomized (GX) rats of both sexes, as well as of GX male and female rats injected subcutaneously with a single dose of 5 microg estradiol benzoate (EB) and/or 2 mg progesterone (P). Animal...

Two experiments were conducted to determine how steroid milieus and pregnancy affect sexual behavior. Experiment 1 was arranged as a Latin square with five ovariectomized cows and five steroid milieus: no steroid (N); progesterone (P4); estradiol benzoate (EB); P4 + EB; and P4 followed by EB (P4:EB). Progesterone was administered via pessary (2 g of P4) for 5 d and EB was injected (1 mg i.m.) o...

The effect of 1,3,5(i 0)-estratriene-3,1 6a,i 7f@-triol(estriol), i ,3,5(i O)-estratriene-2,3-diol-i 7-one (2-hydroxyestrone), and 1,3,5(i 0)-estratriene-2,3,i 7$-triol (2-hydroxyestradiol) on the growth of dirnethylbenz(a)anthracene-induced mammary tumor and of R3230AC-transplantable mammary tumor was corn pared with that produced by estradiol benzoate treatment. Estriol showed minimal inhibit...

Kumar, Ashok and Thomas C. Foster. 17 -Estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons. J Neurophysiol 88: 621–626, 2002; 10.1152/jn.00065.2002. Disruption of Ca homeostasis is hypothesized to mediate several electrophysiological markers of brain aging. Recent evidence indicates that estradiol can rapidly alter Ca -dependent processes in neurons through nongenomic mechan...