Nine human breast cancer cell lines in permanent tissue culture and currently available to researchers have been assayed for their content of cytoplasmic estrogen receptors, progesterone receptors, androgen receptors, and glucocorticoid receptors, as well as for the presence of unfilled or hormone-filled nuclear estrogen receptors. Receptor distribution varied considerably among the nine lines ...

Objectives Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries. This study examined the role of melatonin receptors in the neuroprotective effects of estrogen. Materials and Methods Seventy female ovariectomized Wistar rats were divided into...

INTRODUCTION Several evidences show that muscles have an endocrine function. Glucocorticoid, estrogen, progesterone, and testosterone receptors have already been found in normal skeletal muscles, but not in dystrophic muscles. METHODS The gene expression of hormone receptors was compared between dystrophic and healthy muscles in mdx and C57BL6 mice strains. RESULTS The mdx mice showed a sig...

Phospholipids such as phosphatidyl inositol and phosphatidyl serine inhibit the binding of R5020 and progestin receptors. The effect of phospholipids on the binding of estrogen and estrogen receptors of rat uterine cytosol was studied. Phosphatidyl choline, sphingomyelin, phosphatidyl inositol, phosphatidyl ethanolamine, cardiolipin, and phosphatidic acid inhibited the binding of estradiol and ...

Background The relative absence of coronary atherosclerosis in premenopausal women has been established. Estrogen is presumed to play a role in the protection of coronary arteries from atherosclerosis, and part of this protective effect appears to be mediated by amelioration of serum lipid profiles. However, all of the atheroprotective effect of estrogen is not explained by alteration of serum ...

Breast cancer death polls are rising at an alarming rate in females globally. It is a hormone-dependent disease that majorly regulated by estrogen. Several genetic and environmental factors the primary attributes of breast growth development. A higher proportion patients harbor estrogen receptor-positive (ER+ve) status. Estrogen related receptors orphan nuclear which include ERRα, ERRβ, ERRϒ ex...

Isoflavones are phytoestrogens which have estrogen-like activity in animals and humans with structure similar to 17-β-estradiol and capable of binding to estrogen receptors (ERs).This experiment was conducted to demonstrate the effect of isoflavones on estradiol concentration in blood and its influence on the productive performances in ISA Brown laying hens fed with supplemented feed with large...

The functions of estrogens are relatively well known, however the molecular mechanism of their action is not clear. The classical pathway of estrogen action is dependent on ERα and ERβ which act as transcription factors. The effects of this pathway occur within hours or days. In addition, so-called, non-classical mechanism of steroid action dependent on membrane estrogen receptors (mER) was des...