The purpose of this research was to prepare and evaluate a non-bitter donepezil hydrochloride (DH) orally disintegrating tablet (ODT) for enhanced patient compliance. Taste masking was done by preparing microspheres with different ratios of drug and Eudragit EPO using spray drying method. The entrapment of the drug into microspheres was confirmed by scanning electron microscope (SEM) and X-ray ...

www.pharmtech.com new chemical entity often is first formulated as a free-flowing granulation for encapsulation within hard gelatin capsules. During the course of clinical development, the drugcontaining granulation usually is modified for compaction into a tablet product. The tablet product subsequently may be film coated for taste masking, identification, or other purposes. Tablets are the mo...

the main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. pellet cores of budesonide were prepared by extrusion / spheronization technique. pectin, in different ratios was combined with eudragit rs30d, eudragit ne30d or surelease to produce film coating. the dissolution profiles of pectin coated pellets were investigated in ph of 1.2 (2 ...

Article history: Received on: 23/05/2013 Revised on: 05/07/2013 Accepted on: 01/09/2013 Available online: 30/09/2013 The main objective of the present work was to develop sustained release matrix tablets of Atenolol. To reduce the frequency of administration and to improve the patient compliance, a once daily sustained release formulation of Atenolol is desirable. So sustained release Matrix Ta...

Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

Abstract The main objective of this study was to prepare colon-specific pellets of budesonide using pectin as film coating.  Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH o...

using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. the system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. the system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug...

Objective Eudragits are widely used polymers in the production of oral sustained release dosage forms. The application of these polymers in the production of inert insoluble matrices has been investigated. However the effect of particle size, compaction force and presence of Aerosil 200 as a glidant on the properties of Eudragit RS and RL matrices prepared by direct compression of their physica...

Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young's modulus, and toughness) of these plasticized polymeric films of acrylic (Eudragit RS, RL, and NE) and cellulosic materials (ethyl cellulose (...

The bioactive aqueous extract of Nigella sativa L. seed waste was formulated into soft gelatin capsules (Su1-Su6) in a dose of 200 mg/kg b. w. using different pharmaceutical excipients: soya lecithin/ span80/ sodium taurocholate, PEG 400, and Meglyol 810. The formulations were evaluated for their immunostimmulant and hepatoprotective activities using biochemical methods and for their release by...