Akar pasak bumi (Eurycoma longifolia Jack.) telah lama dimanfaatkan sebagai obat tradisional oleh masyarakat Indonesia aprodisiaka. Ekstraksi akar tumbuhan ini dilakukan dengan berbagai pelarut yang salah satunya menggunakan etanol 70%. Pemilihan untuk memperoleh kandungan zat berkhasiat semaksimal mungkin ditandai rendemen tinggi. Penelitian bertujuan menentukan suhu dan waktu ekstraksi optimu...

BACKGROUND: The brain is very susceptible to damage from oxidative stress due undernutrition. Provision of nutrients and compounds that act as antioxidants needed improve in the brain. AIM: This study was conducted with aim proving potential combination pasak bumi (Eurycoma longifolia Jack), DHA, seluang fish (Rasbora Spp.) brains undernourished rats (Rattus norvegicus). METHODS: Once were unde...

Eurycoma longifolia, locally known as ‘Tongkat Ali’ is a popular local medicinal plant that possess a lot of medicinal properties as claimed traditionally, especially in the treatment of malaria. The claims have been proven scientifically on isolated compounds from the plant. The present study is to investigate the anti malaria properties of Eurycoma longifolia standardized extract (root) (TA16...

OBJECTIVE This study was conducted to investigate the mechanisms of action of Eurycoma longifolia in rat corpus cavernosum. MATERIALS AND METHODS Tincture of the roots was concentrated to dryness by evaporating the ethanol in vacuo. This ethanolic extract was partitioned into 5 fractions sequentially with hexane, dichloromethane (DCM), ethyl acetate, butanol, and water. The corpus cavernosum ...

INTRODUCTION There is little data concerning the ability of Eurycoma longifolia Jack (EL) to reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis. The aim of the present study was to determine the effect of EL on testicular histology and sperm count in estrogen-treated male rats. METHODS Adult male Sprague-Dawley rats weighing 200-250 g were divided into f...

The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited...

Although Eurycoma longifolia has been studied for erectile function, the blood pressure- (BP-) lowering effect has yet to be verified. Hence, this study aims at investigating the BP-lowering properties of the plant with a view to develop an antihypertensive agent that could also preserve erectile function. Ethanolic root extract was partitioned by hexane, dichloromethane (DCM), ethyl acetate, b...

BACKGROUND Toxoplasma gondii infection causes toxoplasmosis, an infectious disease with worldwide prevalence. The limited efficiency of drugs against this infection, their side effects and the potential appearance of resistant strains make the search of novel drugs an essential need. We examined Eurycoma longifolia root extract and fractions as potential sources of new compounds with high activ...

While many people have probably not heard of it, Tongkat Ali has historically been used to treat health problems ranging from fevers to intestinal worms. This herbal extract is most popularly known (no wonder!) as an aphrodisiac for men. Although it comes from a plant in the Southeast Asian rainforests, it is now widely available either as a pill or an instant coffee additive. This herbal suppl...

Androgen-deficient osteoporosis in men is treated with testosterone therapy, which is associated with side effects. Eurycoma longifolia (EL) is known to possess androgenic properties and has been reported to protect bone from androgen-deficient osteoporosis in experimental animal models. The present study aimed to determine the effectiveness of combination therapy of EL and testosterone (T) in ...