Lung transplantation is an effective life-saving therapy for the treatment of a variety of end-stage lung diseases. However, the application of lung transplantation is hindered by multiple factors such as the shortage of organ donors, early graft failure, infection, and chronic graft dysfunction. A novel strategy for donor lung preservation--ex-vivo lung perfusion (EVLP)--that keeps the organ a...

Several studies have confirmed the role of hydrogen to scavenge reactive oxygen species (ROSs) and to protect against ischaemic reperfusion injury (IRI) in the lung and the heart [1–4]. In a study, where rabbit lungs were exposed to ex vivo lung perfusion (EVLP), the infusion of H2S significantly reduced ROS activity within the grafts [4]. This resulted in a significant decrease of lipid peroxi...

Combination of the in vivo thorax trauma model with ex vivo lung perfusion 86