Tecfidera has been shown to be of benefit in relapsing multiple sclerosis in two Phase III clinical trials. In the DEFINE trial, the medication produced a 49% reduction in the proportion of people who experienced relapses over 2 years, and had a similar significant impact on disease activity detected on MRI., This resulted in a 38% reduction in the risk of confirmed progression of disability as...

Objectives: Multiple Sclerosis (MS) is a chronic and disabling disease of the nervous system. This study was conducted to determine the effect of isometric exercises on balance and ability in the patients with MS.  Methods: Sixty MS patients participated in this randomized controlled trial study and patients were randomly assigned into treatment and control groups. Treatment group partici...

Background and aims: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system.The impact of the number of attacks on the disease is undeniable. The aim of this study was to analyze thenumber of attacks in these patients.Methods: In this descriptive-analytical study, the registered data of 1840 MS patients referred to the MS clinicof Ayatollah Kash...

OBJECTIVES To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen. METHODS A long term (more than five years) observational longitudinal follow up study assessing 21 patients who received intrathecal baclofen given by programmable pump. Patients had chronic disabling spasticity which did...

BACKGROUND Neuromyelitis optica (NMO) is an inflammatory disease with combined features of optic neuritis and myelitis. This pathologic entity may induce severe disability, including visual loss and paraplegia. Other than clinical follow-up, there is no marker for severity of the disease. OBJECTIVES To evaluate the use of optical coherence tomography (OCT) in NMO and to determine whether this...

aim and background: schemas are cognitive patterns that have a major impact on the perception and behavior. therefore, it is necessary to investigate their role in determining and changing health related behaviors in ms patients. the purpose of this study is to investigate the mediating effect of illness perception on the relationship between early maladaptive schemas in the domain of rejection...

    Background: Dysphagia is frequently observed in patients with multiple sclerosis (MS). Dysphagia and its complications are common causes of morbidity and mortality in final stages of MS disease. This study aimed at determining the prevalence of dysphagia in Iranian patients with MS and identifying predictors associated with dysphagia.    Methods: A total of 230 MS ...