The Working Group that evaluated smokeless tobacco previously noted that the majority of the early studies evaluated at that time (IARC, 1985) had various deficiencies, such as lack of quantitative and qualitative information on the nature of tobacco extracts and the degree of extraction, insufficient length of treatment, small group sizes and, in some cases, lack of appropriate controls. Since...

Adult rabbits were given single intravenous injections of 25 mg. per kilogram of sodium dicloxacillin. At intervals of time ranging from 15 minutes to 8 hours after injection, primary or secondary aqueous humor was aspirated from each eye. At the same time, a specimen of cardiac blood was withdraion. Other animals were given subconfunctival injections of 50 mg. of dicloxacillin. Aqueous humor w...

Previous studies carried out with Sm14 in experimental vaccination against Schistosoma mansoni or Fasciola hepatica infections were performed with recombinant Sm14 (rSm14) produced in Escherichia coli by the pGEMEX system (Promega). The rSm14 was expressed as a 40 kDa fusion protein with the major bacteriophage T7 capsid protein. Vaccination experiments with this rSm14 in animal models resulted...

Anticoagulant activity of acenocoumarin (Sintrcm) has been determined in dogs, Prothrombin values were determined according to modified Quick's method (Montigel 1962). Prothrombin index and coagulation valency were deduced from the prothrombin time. The results were compared with the reference drug ethylbiscoumacetate. Acenocoumarin was found to be 60 times more potent than ethylbiscoumacetate....

. [2] Barnes, R.H. and Fiala, G. (1958). Effects of the prevention of coprophagy in the rat II. Vitamin B12 requirement.J. Nutr., 65, 103-114. [3] Barki., V.H., Derse, P.H., Collins, R.A., Hart, E.B., and Elevehjem, C.A. (1949). The influence of coprophagy on the biotin and folic acid requirements of the rat. J. Nutr., 37, 443-456. [4] Bjð±rnhag, G. (1981). Separationand retrograde tran...

Asbestos has been established as the cause of most cases of diffuse malignant mesothelioma occurring in the industrialized world. The morphology of mesothelioma may be complex, and the employment of chemical, histochemical and ultrastructural studies are often helpful in identification. Diagnostic difficulties may to some degree blur the extent of its prevalence and reliance on exposure history...

Polychlorinated biphenyls (PCBs) are well known to reduce the concentrations of thyroid hormones in the circulation of experimental animals (Bastomsky et al., 1976; Brouwer et al., 1998). Moreover, circulating levels of PCBs have been reported to co-vary with various measures of thyroid status in humans (Koopman-Esseboom et al., 1997; Osius et al., 1999). These observations form the basis for t...