Introduction: Keratoconus is a relatively common disease of cornea in which structural changes within the cornea cause it to thin and change to a conical shape and scar at the central portion of cornea. So far, few methods and drug treatments were introduced due to both lack of accepted animal models to induce experimental keratoconus and limitation of research in human considering ethical issu...

A two-stage method for the computational prediction of the structure of protein-ligand complexes is proposed. Given an experimentally determined structure of the protein, in the first stage a large number of plausible ligand conformations is generated using the fast docking algorithm FlexX. In the second stage these conformations are minimized and reranked using a method based on a classical fo...

residual stress measurement has gained interests among researchers for many years due to its great influence on the structural integrity. slitting method is one of the destructive techniques that relies on the introduction of an increasing cut to a part containing residual stresses. similar to all other mechanical strain relief techniques, slitting also suffers from its shortcomings during the ...

This study aims to extract Glycyrrhizic Acid (GA) from Glycyrrhiza glabra L. (licorice) using a novel, high efficiency, and low-cost extraction method. Water was chosen as the proper solvent for the extraction process to eliminate the requirement of harmful and toxic solvents, prepare an environmentally friendly process, and reduce the costs. The effect of differe...

this paper presents an efficient hybrid method, namely fuzzy particleswarm optimization (fpso) and fuzzy c-means (fcm) algorithms, to solve the fuzzyclustering problem, especially for large sizes. when the problem becomes large, thefcm algorithm may result in uneven distribution of data, making it difficult to findan optimal solution in reasonable amount of time. the pso algorithm does find ago...