A population survey of 258 unrelated white British subjects showed a polymorphism for the 4-oxidation of debrisoquine. "Extensive metabolisers" (EM) and "poor metabolisers" (PM) are recognisable, 8.9% of the population being PM. Nine pedigrees ascertained through PM probands show that the PM phenotype is an autosomal Mendelian recessive character. The EM phenotype is dominant and the degree of ...

Extensive limb swelling (ELS) has been reported after vaccination with a limited number of vaccine types. We sought to describe vaccine types involved in and the clinical characteristics of ELS cases reported to the Vaccine Adverse Event Reporting System (VAERS). A case of ELS was defined as any report of edema extending at least to the elbow or knee of a vaccinated extremity. Four hundred nine...

PURPOSE To determine whether maintenance therapy with carboplatin and etoposide improves progression-free and overall survival in patients with extensive stage small cell lung cancer, compared to the standard four to six cycles of cisplatin and etoposide. METHODS Forty-two patient records (25 males and 17 females) were retrospectively reviewed in a single community practice. All patients were...

The objective of this retrospective study was to investigate prognostic factors associated with survival of patients with extensive stage small cell lung cancer (ES-SCLC). Included were 200 patients admitted to the Liberation Army General Hospital with a diagnosis of ES-SCLC. The demographics of patients, disease characteristics, pre-treatment biochemical parameters and therapeutic plan were as...

The article in this issue of ONCOLOGY by Kelsey et al differs very little from a recent publication on the issue of early Hodgkin lymphoma (HL) therapy from radiation oncologists.[1] These have been matched by editorials that question the role of radiation therapy in early HL, especially in nonbulky favorable presentations.[2-7] The argument that extensive radiation fields and doses have both b...

Medulloblastoma with extensive nodularity is a rare subtype of the most common malignant childhood brain tumor and has been associated with more favorable prognosis. The authors report the case of a 10-month-old girl with a posterior fossa tumor of excessive nodularity with decreased diffusivity on diffusion-weighted magnetic resonance imaging sequences and robust grape-like postgadolinium cont...

AIM To study the kinetic characteristics of lansoprazole in healthy Chinese subjects in relation to CYP2C19 genotype status for the individualized dose regimen of lansoprazole. METHODS Nine homozygous extensive metabolizers (homo EMs) and 9 poor metabolizers (PMs) were recruited for the study from a total of 70 healthy Chinese volunteers, whose CYP2C19 genotype status was determined by the PC...

competition is against monopoly and intellectual property creates monopoly for intellectual property owner. this article had been paid cooperation between apparently contradictory policies. exhaustion, parallel imports, compulsory license, intellectual property exploitation contract that coincide with competition are methods of cooperation between intellectual property and competition law. comp...

By using an alternative, equivalent form of the CHSH inequality and making extensive use of the experimentally testable property of physical locality we determine the 64 different Bell-type inequalities (each one involving four joint probabilities) into which Hardy’s nonlocality theorem can be cast. This allows one to identify all the two-qubit correlations which can exhibit Hardy-type nonlocal...

Deltamethrin, a type-II synthetic pyrethroid with potential insecticidal property is extensively used as used as an ectoparasiticide in crop protection and public health programme.1 Extensive studies on animals revealed that deltamethrin are particularly toxic to neurons, acting directly on the axon by interference with sodium channel gating mechanism that underlines the generation and conducti...