This study aimed to assess the steady-state pharmacokinetics of pranlukast, a leukotriene receptor antagonist, in children with allergic rhinitis and bronchial asthma, and to clarify factors affecting apparent clearance (CL/F). A total of 192 plasma samples were obtained from 98 children (rhinitis 64, asthma 13, complications 21), aged 3-14 years in 2 clinical trials. Plasma concentration of pr...

The apparent oral clearance (CL/F, mL/min) of busulfan was measured in 279 adolescent and adult patients. Significant (P <.05) determinants of CL/F by linear regression were: actual body weight (BW; r2 = 0.300), body surface area (BSA; r2 = 0.277), adjusted ideal body weight (AIBW; r2 = 0.265), and ideal body weight (IBW; r2 = 0.173); whereas body mass index (BMI), height, age, gender, and dise...

orofacial clefts, including cleft lip with or without cleft palate (cl (p)), are common congenital malformations, second only to clubfoot in frequency of occurrence. the epidemiology and genetics of this disorder have been studied extensively in various countries by several investigators. the objective of this study is to assess the epidemiology and some genetic aspects of orofacial clefting at...

The first synthesis of 4 ́-X-phenylverbenene (X = F and Cl) via reaction of myrtenal with 4 -X phenylmagnesium bromide and Bi(NO3)3 is described. Verbenene is formed due to the electron-withdrawing effect of the 4 electronegative group, either fluorine or a Cl–Bi complex.

We are interested in a game-theoretic approach to proving satisfiability of LTL formulæ. We consider for this LTL formulæ in negative normal form, i.e. using the abstract syntax ' ::= p ∣ ¬p ∣ ' ∨ ' ∣ ' ∧ ' ∣ X' ∣ ' U ' ∣ ' R ' , where p ranges over a non-empty finite set of atomic propositions AP. Let ⊤ ≡ p ∨ ¬p and ⊥ ≡ p ∧ ¬p for some atomic proposition p. The F and G modalities are defined a...

o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o o We review the pr gress that has been made in bserving and analyzing m lecular cl ud structure in recent years. Structures are self-similar ver a wide range f scales, with similar p wer law indexes, independent f the star-f rming nature f a cl ud. C mparis n f structures at parsec-scale res lu...