BACKGROUND In highly sensitized patients (HSP) awaiting renal transplantation, accurate delineation of acceptable human leukocyte antigen (HLA) mismatches (AMM) aids identification of suitable crossmatch negative donors. Comparison of differences in polymorphic triplet amino acid sequences in antibody accessible regions of HLA may predict immunogenicity. We have examined the ability of the HLAM...

Mismatch repair of palindromic loops in the presence or absence of single-base mismatches was investigated in wild-type and mismatch-binding defective mutant Chinese hamster ovary cells. Recombination intermediates with a maximum heteroduplex DNA (hDNA) region of 697 bp contained a centrally located, phenotypically silent 12-base palindromic loop mismatch, and/or five single-base mismatches. In...

In this paper, we model time-interleaved analog-to-digital converters (TIADCs) with nonlinear hybrid filter banks (NHFBs), which greatly unifies and simplifies the analysis of TIADCs. The input/output relation of such a nonlinear hybrid filter bank can be used to describe combined offset, gain, aperture delay, input behavior, and nonlinearity mismatches and is therefore an extendable starting p...

Mismatches make COTS components difficult to be incorporated. In this paper, an approach is presented to eliminate mismatches among COTS components, which can truly consider COTS components as black boxes. In the approach, only the assembly description of components is required, based on which adaptors for resolving mismatches can be generated automatically. This paper also described an agent-b...

The growth of the Internet has revitalised research on the integration of heterogeneous information sources. Integration efforts face a trade off between interoperability and heterogeneity. Important integration obstacles arise from the differences in the underlying ontologies of the various sources. In this paper we investigate the impediments to integration, focussing on ontologies. In partic...

Donor-recipient human leukocyte antigen mismatch level affects the outcome of unrelated cord blood (CB) transplantation. To identify possible "permissive" mismatches, we examined the relationship between direction of human leukocyte antigen mismatch ("vector") and transplantation outcomes in 1202 recipients of single CB units from the New York Blood Center National Cord Blood Program treated in...

Does the nervous system continuously realign the senses so that objects are seen and felt in the same place? Conflicting answers to this question have been given. Research imposing a sensory mismatch has provided evidence that the nervous system realigns the senses to reduce the mismatch. Other studies have shown that when subjects point with the unseen hand to visual targets, their end points ...

Qualitative mismatches arise when the qualifications or skills of workers, individually or in the aggregate, are different from the qualifications or skills required or specified for their jobs. This review develops the distinction between short run mismatches occurring between workers and jobs and long run aggregate mismatches that arise from shifts in supplies and demands for workers. The rev...