sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (cns). despite cd4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis.nonetheles...

Urogenital sarcoidosis is very rare. To date, only about 60 cases have been described in the literature.1 This corresponds to only 0.2% of all cases of sarcoidosis diagnosed. When the urogenital system is affected, it is usually the epididymis that is involved, followed by the testis and vas deferens.2 Sarcoidosisealso known as Boeck's sarcoid or Schaumann-Besnier diseaseeis a rare chronic diso...

Background: Sarcoidosis is a granulomatous multisystem disease of unknown etiology. It has recently been tired to detect Mycobacteria genome in biopsy specimens of patients with sarcoidosis by Polymorphism chain reaction method. Objective: To detect and identify Mycobacteria species in cutaneous lesions of the patients with sarcoidosis by PCR-RFLP. Patients and methods: 20 patients with clinica...

purpose: to describe a patient with eyelid sarcoidosis. case report: a 54 year-old patient was referred for an eyelid mass from 6 months ago.excisional biopsy showed inflammatory granuloma with tuton gaint cells. chest radiograph demonstrated bilateral hilar adenopathy, increased absorption on gallium scan was noted and bronchoalveolar lavage confirmed a diagnosis of sarcoidosis. treatment with...

Sarcoidosis is a clinicopathologic syndrome resulting from dispersed organ involvement by a noncaseating granulomatous process of unknown cause. The clinical manifestations of sarcoidosis are protean, depending on the affected organs; however, the principal targets of sarcoidosis are the lungs and thoracic lymph nodes, which almost always are involved. As a rule, it is a disease of insidious on...

BACKGROUND A polymorphism (rs35705950) 3 kb upstream of MUC5B, the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF). We set out to verify whether this variant is also a risk factor for fibrotic lung disease in other settings and to confirm the published findings in a UK Caucasian IPF population. METHODS Caucasian U...

Monogenic autoinflammatory syndromes (MAISs) are caused by innate immune system dysregulation leading to aberrant inflammasome activation and episodes of fever and involvement of skin, serous membranes, eyes, joints, gastrointestinal tract, and nervous system, predominantly with a childhood onset. To date, there are twelve known MAISs: familial Mediterranean fever, tumor necrosis factor recepto...