Abstract Harvesting individuals for translocations can negatively impact source populations, a critical challenge species reduced to small populations. Consequently, translocation cohorts often remain small, reducing the establishment probability at destination. Balancing potential benefits and risks of such is further complicated by philopatry natural metapopulation dynamics if target highly m...

the highly conserved morphology and chromosomal structures of house mouse, mus musculus, provides a good model for chromosomal studies. sex-autosome translocations is one of the rarest chromosomal rearrangements among mammals and therefore sex-autosome translocations has been offered as accurate taxonomic markers to identify species with similar morphological traits. in this study, we described...

Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been...

Carnivore conservation translocations are assumed to provide numerous ecological benefits, including of the translocated carnivores, regulation prey species and restoration ecosystems. Reviews mammalian carnivore resultant ecosystem effects have focussed on large carnivores. We reviewed global terrestrial across all taxa, taxonomic bias, problems influencing their population establishment effec...

background: robertsonian translocations are structural chromosomal abnormalities caused by fusion of two acrocentric chromosomes. in carriers of such translocations, different modes of segregations would result in the formation of either balanced (alternate segregation mode) or unbalanced (adjacent 1, adjacent 2, and 3:1 segregation modes) gametes. in addition, there is an increased risk for im...

Translocations involving the anaplastic lymphoma kinase (ALK) gene locus on chromosome 2p23 were first described in anaplastic large cell lymphoma (ALCL). Although most commonly fused to the nucleophosmin (NPM1) gene on chromosome 5q35, which results in the t(2;5)(p23;q35)/NPM1-ALK translocation, several other ALK translocation partners have meanwhile been identified. Furthermore, apart from AL...

MYC translocations represent a genetic subtype of T-lineage acute lymphoblastic leukemia (T-ALL), which occurs at an incidence of ∼6%, assessed within a cohort of 196 T-ALL patients (64 adults and 132 children). The translocations were of 2 types; those rearranged with the T-cell receptor loci and those with other partners. MYC translocations were significantly associated with the TAL/LMO subty...

Translocations involving an MYC gene (c >> N >>L) are very late tumor progression events and provide a paradigm for secondary translocations in multiple myeloma. Using a combination of fluorescent in situ hybridization and comparative genomic hybridization arrays (aCGH), we have identified rearrangements of an MYC gene in 40 of 43 independent myeloma cell lines. A majority of MYC translocations...

Yeast species have undergone extensive genome reorganization in their evolutionary history, including variations in chromosome number and large chromosomal rearrangements, such as translocations. To determine directly the contribution of chromosomal translocations to the whole organism's fitness, we devised a strategy to construct in Saccharomyces cerevisiae collinear "evolutionary mimics" of o...

Most, if not all, malignancies have recurrent and disease-specific clonal chromosomal abnormalities, which play a pivotal role in tumor development. These comprise deletions or amplifications involving entire chromosomes or subchromosomal regions and, also, translocations. The latter represent the juxtaposition of fragments of DNA that are usually on different chromosomes. Most translocations a...