نتایج جستجو برای: fatty acid synthase
تعداد نتایج: 864452 فیلتر نتایج به سال:
Chicken liver fatty acid synthase is inhibited by the thiol-modifying reagents 5,5'-dithiobis-(2-nitrobenzoic acid) and iodoacetamide. Total inactivation of the activity for fatty acid synthesis requires the modification of about 8 of the nearly 50 freely accessible thiol groups per molecule. The differential binding of iodo[14C]acetamide to phenylmethylsulphonyl fluoride-modified enzyme in the...
Bioassay-guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G (1), together with six known compounds, gemin A (2), casuarinin (3), pedunculagin (4), potentillin (5) , tellimagrandin II (6), and ellagic acid (7). Their structures were determined on the basis of sp...
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the...
Hyperlipidemia refers to elevated levels of lipids and cholesterol in the blood. It plays an important role development atherosclerosis, main cause death world. Medicinal plants can lower blood by many mechanisms included inhibition expression fatty acid synthase, decreasing free release, HMG-CoA reductase, increasing fecal excretion fat cholesterol, activity pancreatic lipase absorption. The c...
An assessment of the transcript abundance of several fatty acid and lipid biosynthetic genes has been made. Total RNA was extracted from embryos at different stages of development and mRNA was analysed by quantitative Northern blots and used to probe cDNA arrays. Central fatty acid synthase components were present at different steady-state levels, but at constant ratios throughout development; ...
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