The present study was performed to determine the prevalence of FIV in stray cat's population of Ahvaz different area. Serum samples were collected from 90 cats from 2005 to 2007. The studied cats were divided into two age groups (3 years) and based on clinical signs (such as lymphadenopathy, periodontal diseases, gingivitis, abscess and cashecsi) into two groups also. The results were analyzed ...

With the exception of human immunodeficiency virus (HIV), which emerged in humans after cross-species transmissions of simian immunodeficiency viruses from nonhuman primates, immunodeficiency viruses of the family Lentiviridae represent species-specific viruses that rarely cross species barriers to infect new hosts. Among the Felidae, numerous immunodeficiency-like lentiviruses have been docume...

Abstract An adult, mixed-breed, feline leukaemia virus (FeLV-) positive female cat was presented with mucosal jaundice and a history of anorexia constipation for three days. Physical examination revealed splenomegaly, cachexia, dehydration. Humane euthanasia conducted, followed by postmortem examination. Grossly, the icteric, hepatomegaly multifocal white spots splenomegaly. Histologically, bon...

A cat was presented with severe progressive anemia despite marked erythroblastosis. The cat was negative for feline leukemia virus antigen and feline immunodeficiency virus antibody. Bone marrow cytology revealed an excess of erythroid cells with a predominance of prorubricytes and basophilic rubricytes. No response to immunosuppressive therapy was obtained, and a tentative diagnosis of myelody...

Gingivostomatitis (GS) is a significant condition in cats because of oral discomfort and associated periodontal disease. Several infectious agents have been associated with the presence of GS, but a causal relationship is unclear. The cats in this study were housed together, had a history of flea exposure, and were vaccinated with a modified live FVRCP product. There were nine cats with active ...

The feline homologue of CD134 is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells. However, strains of FIV differ in utilization of CD134; the prototypic strain PPR requires a minimal determinant in the first cysteine-rich domain (CRD1) of feline CD134 to confer near-optimal receptor function, while strains...

Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we demonstrate that bicyclams are potent inhibitors of feline immunodeficiency virus (FIV) replication when evaluated in Crandell feline kidney (CRFK) cells. With a series of bicyclam derivatives, 50% inhibitory...

Lentiviruses (LV) are nononcogenic viruses, belonging to the Lentivirinae subfamily. The name comes from the Latin word “lenti”, meaning “slow”. According to the definition of B. Sigurdsson, they are causing infections in a limited number of hosts with a long incubation period (months and years) and progressive course, accompanied by damage in definite organs/tissues and a lethal outcome (Sigur...