In Iranian traditional medicine, there are some report regarding the anticonvulsant effect of Ferula gummosa Boiss. In this study, anticonvulsant activity, neurological deficits and lethality of the root acetone extract of this plant were evaluated in mice. The extract exhibited dose-dependent prevention of tonic seizures induced by pentylenetetrazole (ED50 = 154.4 mg/kg). However, the extract ...

The germination of Ferula ovina seeds faces certain problems. The present research was designed to study the promotion of the germination of Ferula ovina seeds by moist-chilling and GA3 applications. The results showed that Ferula ovina seeds display an endogenous dormancy that can be released by moist-chilling treatment for a certain period. In this respect, the best treatment was moist-chilli...

Ferula turcica and latialata are two novel endemic species discovered in the Konya Kırşehir provinces of central Anatolian region Türkiye. These new described by morphological, ecological, carpological, phytochemical characteristics phylogenetic analysis. F. morphologically distinct from szowitsiana their habit, stalk terminal umbella, mericarp size, as well profile secondary metabolite markers...

Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identi...

Essential oils from Ferulago asparagifolia Boiss., F. galbanifera (Miller) W. Koch, F. humilis Boiss. (Endemic), F. trachycarpa Boiss. growing in Turkey were evaluated against 15 microorganisms for their antifungal and antibacterial activity using an agar tube dilution and microdilution broth susceptibility assay, respectively. The essential oil compositions were investigated by GC/MS. Inhibito...