A novel stability-indicating gradient RP-UPLC method was developed for the quantitative determination of process related impurities and forced degradation products of fexofenadine HCl in pharmaceutical formulations. The method was developed by using Waters Aquity BEH C18 (100 mm x 2.1 mm) 1.7 μm column with mobile phase containing a gradient mixture of solvent A (0.05% triethyl amine, pH adjust...

Fexofenadine, a nonsedating antihistamine, does not undergo significant metabolic biotransformation. Accordingly, it was hypothesized that uptake and efflux transporters could be importantly involved in the drug's disposition. Utilizing a recombinant vaccinia expression system, members of the organic anion transporting polypeptide family, such as the human organic anion transporting polypeptide...

A simple reversed phase high performance liquid chromatographic method with diode array detector (HPLC-DAD) has been developed and subsequently validated for the determination of fexofenadine hydrochloride (FEX) and its related compounds; keto fexofenadine (Impurity A), meta isomer of fexofenadine (Impurity B), methyl ester of fexofenadine (Impurity C) in addition to the methyl ester of ketofex...

The authors of the article describe dependence effectiveness any drug on "correctness" its choice for patient and conclude that profiling can serve as an effective clinical method selecting optimal therapy. When prescribing antihistamines, it is suggested to use following main profiles: children, working adults, elderly patients. Each profile has own specific purpose.
 presents experience ...

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Simple and accurate spectrophotometric and HPLC method was developed for determination of Fexofenadine in tablets dosage form. The spectrophotometric method was developed by dissolving tablets in 1:1 Methanol to make solution of 10ppm giving absorbance at 220nm. The experimental conditions were optimized and Beers law was obeyed over the applicable concentration range. The application of HPLC p...

We examined the effects of two over-the-counter H1-antihistamines on the progression of fatty liver disease in male C57Bl/6 wild-type and apolipoprotein E (ApoE)-/- mice. Mice were fed a high-fat diet (HFD) for 3 mo, together with administration of either cetirizine (4 mg/kg body wt) or fexofenadine (40 mg/kg body wt) in drinking water. Antihistamine treatments increased body weight gain, gonad...

H1-antihistamines, the mainstay of treatment for urticaria, were developed from anticholinergic drugs more than 70 years ago. They act as inverse agonists rather than antagonists of histamine H1-receptors which are members of the G-protein family. The older first generation H1-antihistamines penetrate readily into the brain to cause sedation, drowsiness, fatigue and impaired concentration and m...

A simple, precise and low cost conductometric method for the determination of alfuzosin hydrochloride and fexofenadine hydrochloride in pure form and pharmaceutical formulations using sodium tetraphenylborate has been described. The method is based on the formation of ion association complex of cations coming from the cited drugs with tetraphenylborate anions and the conductance of the solution...