a rhamnolipid–type biosurfactant production by pseudomonas aeruginosa mm1011 was studied in a miniaturized shaken bioreactor. the operational parameters, affecting the biosurfactant production in shaken bioreactors, such as shaking frequency (200, 250, 300 rpm), filling volume (50, 75, 100 ml), and aeration rate (0.2, 0.6, 1 vvm), were optimized using response surface methodology. the optimizat...

OBJECTIVES The aim of this study was to set up reference values for Doppler flow-derived left ventricular filling parameters and to evaluate physiologic determinants of changes in signal expression related to maturation. BACKGROUND In left ventricular diastolic function studies, age-related modulations in signal expression are observed. Assuming degenerative myocardial changes to be absent du...

BACKGROUND Cardiac magnetic resonance (CMR) is established for assessment of left ventricular (LV) systolic function but has not been widely used to assess diastolic function. This study tested performance of a novel CMR segmentation algorithm (LV-METRIC) for automated assessment of diastolic function. METHODS AND RESULTS A total of 101 patients with normal LV systolic function underwent CMR ...

Alteration of extra-embryonic venous blood flow in stage-17 chick embryos results in well-defined cardiovascular malformations. We hypothesize that the decreased dorsal aortic blood volume flow observed after venous obstruction results in altered ventricular diastolic function in stage-24 chick embryos. A microclip was placed at the right lateral vitelline vein in a stage-17 (52-64 h of incubat...

In patients with heart failure, decreased contractility resulting in high end-diastolic pressures and a restrictive pattern of left ventricular filling produces a decrease in early diastolic filling, suggesting a stiff ventricle. This study investigated the elastic properties of the myocardium and left ventricular chamber and the ability of the heart to utilize elastic recoil to facilitate fill...

In a past study of hyperoxia-induced lung injury, the extensive lymphatic filling could have resulted from lymphatic proliferation or simple lymphatic recruitment. This study sought to determine whether brief lung injury could produce similar changes, to show which lymphatic compartments fill with edema, and to compare their three-dimensional structure. Tracheostomized rats were ventilated at h...

TO THE EDITOR: I read with interest the Viewpoint article by Zhang et al. (5). The authors advocated dPLV (ventricular pressure)/dVLV (ventricular volume) 0 as the necessary and sufficient condition for definition of diastolic suction. This definition guarantees that suction manifests only when ESV (end-systolic volume) Veq [equilibrium volume (diastasis volume)] and naturally leads to the kine...