context in human beings, uric acid is the poorly soluble circulating end product of the purine nucleotide metabolism. a reduction in the glomerular filtration rate (gfr) contributes to hyperuricemia, which is frequently observed in patients with chronic kidney disease (ckd). evidence acquisition hyperuricemia is defined as a serum uric acid level > 7.0 mg/dl in males and > 6.0 mg/dl in females,...

We aimed at reviewing age-related changes in kidney structure and function, methods for estimating kidney function, and impact of reduced kidney function on geriatric outcomes, as well as the reliability and applicability of equations for estimating glomerular filtration rate (eGFR) in older patients. CKD is associated with different comorbidities and adverse outcomes such as disability and pre...

Resistin, Glomerular Filtration Rate, and Insulin Resistance To the Editor: The recent article by Ellington et al1 showed a significant inverse relationship between circulating resistin levels and estimated glomerular filtration rate (eGFR) in hypertensive adults without cardiovascular disease. This association was independent of markers for insulin resistance and inflammation, suggesting that ...

Glomerular filtration rate (GFR) is usually accepted as the best overall index of kidney function in health and disease. Normal GFR varies according to age, sex, and body size. In young adults it is approximately 120-130ml/ min/1.73 m2 and declines with age1. A decrease in GFR precedes the onset of clinical kidney failure; therefore, a persistently reduced GFR is a specific indication of chroni...

1. The effect of infusion of ovine prolactin was studied in anaesthetized dogs pretreated with bromocryptine to reduce the release of endogenous prolactin. 2. Prolactin, injected intravenously and also directly into one kidney, resulted in a 12--18% increase in glomerular filtration rate (GFR) by both kidneys. 3. This increased GFR was not associated with any demonstrable changes in whole-kidne...

Preventing coronary heart disease: high baseline risk strategy and cost effectiveness of guidelines' BMJ, vol 332, no. 7544, pp. 793. General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requir...

Hyponatremia affects nearly one in five of all hospitalized patients. Severe hyponatremia is associated with significant morbidity and mortality, and is therefore important to recognize. Prior reports have linked duloxetine with hyponatremia, but it is uncommon. In this case report, we describe a research subject taking duloxetine who developed severe symptomatic hyponatremia during glomerular ...

Chronic kidney disease (CKD) is a common health problem worldwide. CKD staging or classification, together with patients’ prognosis and treatment plan depend on the patients’ kidney function which is assessed by measurement of glomerular filtration rate (GFR). Estimated GFR can be obtained using serum or plasma creatinine as a main variable in equations or formulae such as Cockcroft-Gault equat...

UNLABELLED In order to be able to compare individuals of differing size, glomerular filtration rate (GFR) is conventionally indexed to body surface area (BSA). This does not, however, suit children because they naturally have a relatively high BSA simply because of their small size. The aim of the study was to identify an appropriate simple whole-body variable based on height and weight suitabl...