We describe a 17-year-old girl with haemolytic anaemia as presentation of Wilson disease. The diagnosis was based on the findings of < 20 mg/dl ceruloplasmin serum level, Kayser-Fleischer ring and Coombs-negative haemolytic anaemia. Genetic testing revealed the presence of the H1069Q heterozygous mutation. The patient was treated with Zinc acetate monotherapy, with good response, maintened afte...

We present a patient with chronic postmenopausal estrogen intake with presence of Kayser-Fleischer ring in the cornea and Alzheimer's disease and discuss the pathophysiological mechanisms of estrogen intake and copper accumulation in various tissues, including the central nervous system. Sonography was compatible with copper accumulation in the basal ganglia, but the patient showed no clinical ...

BACKGROUND The purpose of this report was to describe a single case of recurrent interstitial keratitis in a young patient leading to keratoconus-like corneal changes. RESULTS Over the 2 years follow-up, the patient developed clinical signs of keratoconus with Vogt's striae, Fleischer Ring and paracentral stromal thinning in the affected eye only. The tomographic measurements revealed a rapid...

We settle an open problem mentioned in Diaz, Petit, and Serna: A survey of graph layout problems (ACM Computing Surveys 34:313–356, 2002). Of eight objectives considered in that survey, only the complexity status of minimum vertex bisection is listed as unknown. We show that both minimum and maximum vertex bisection are NP-hard, but polynomially solvable on special graph classes such as hypercu...

Article history: Received 11 November 2007 Received in revised form 20 November 2008 Accepted 20 November 2008 Available online 11 December 2008 Communicated by R. Fleischer

Here we describe a case of a 22-year-old woman who presented with acute liver failure and Kayser-Fleischer rings suggesting the diagnosis of Wilson's disease.

1. FLEISCHER J., DEUCHERT M., RUHS C., KÜHLEWEIN HALVADJIYSKY G., SCHMIDT 2008, Design and Manufacturing of Micro Milling Tools, Microsyst. Technol., 14, 1771–1775. Google Scholar

Fleischer and Mannel (FM) have shown that it may become possible to constrain the angle γ of the unitarity triangle from measurements of various B → πK decays. This constraint is independent of hadronic uncertainties to the few percent level. We show that, within the Standard Model, the FM bound gives strong constraints on the CKM parameters. In particular, it could predict a well defined sign ...