We report direct numerical simulations of the flow around a spanwise-flexible wing in forward flight. The were performed at $Re=1000$ for wings aspect ratio 2 and 4 undergoing heaving pitching motion Strouhal number $St_c\approx 0.5$ . have varied effective stiffness $\varPi _1$ while keeping inertia constant, _0=0.1$ It has been found that there is an optimal aerodynamic performance linked to ...

Interference with microtubule polymerization results in cell cycle arrest leading to cell death. Colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. A set of 3',4'-bis (substituted phenyl)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one derivatives with known antiproliferative activities were evaluated for their tubulin binding modes...

Interference with microtubule polymerization results in cell cycle arrest leading to cell death. Colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. A set of 3',4'-bis (substituted phenyl)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one derivatives with known antiproliferative activities were evaluated for their tubulin binding modes...