The present investigation deals with the optimization, formulation, and characterization of oral in situ gel of spiramycin. Sodium alginate and hydroxypropyl methylcellulose were used as cross-linking and viscosifying agents, respectively. Sodium bicarbonate was used as a floating agent. In preformulation studies, the melting point, pH, and partition coefficient were found to be 133 °C, 9.5, an...

For linear systems with pointwise or distributed delay in the inputs which are stabilized through the reduction approach, we propose a new technique of construction of Lyapunov-Krasovskii functionals. These functionals allow us to establish the ISS property of the closed-loop systems relative to additive disturbances.

Abstract This paper proposes an alternative estimation method for cointegration, which allows variation in the leads and lags cointegration relation. The is more powerful than a standard method. Illustrations to annual inflation rates Japan USA seasonal quarterly consumption income shows its ease of use empirical merits.

The objective of the present investigation was to develop a bilayer-floating tablet (BFT) for captopril using direct compression technology. HPMC, K-grade and effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The release layer contained captopril and various polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or in combination with the drug. The floa...

the present investigation was focused to formulate semi-solid capsules (sscs) of hydrophobic drug telmisartan (tlms) by encapsulating semi-solid matrix of its solid dispersion (sd) in hpmc capsules. the combinational approach was used to reduce the lag time in drug release and improvise its dissolution. sds of tlms was prepared using hot fusion method by varying the combinations of pluronic-f68...

Abstract: Aim: Hypertension exhibits a circadian rhythm and drugs need to be released at the time when blood pressure is elevated most. This elevation pronounced 7 pm 4 am. Atenolol an anti-hypertensive drug with absorption window mainly in upper section of gastrointestinal tract. The present investigation was aimed designing floating pulsatile capsules for dual release atenolol stomach effecti...

Floating drug delivery system provides the advantage of sustained release of drugs over a prolonged period of time thereby maximising the oral absorption of drugs with narrow absorption window, thus, it overcomes the drawback of conventional oral drug delivery system. In situ gelling system is a novel approach in this regard. The aim of the present work was to develop an oral sustained stomach ...

This study uses the Autoregressive Distributed Lag (ARDL) model to study the dynamic determinant factors that influence both long and short-term international tourism demand in Cambodia from 12 countries. The annual time series data (1994–2013) are used in this study. The study finds that only the international tourism demand model of Australia, Canada, Thailand, the United Kingdom, and USA are...