The effect of furosemide on gentamicin excretion and tissue accumulation was studied with clearance techniques in anesthetized rats, at two different infusion rates of saline or Ringer solution. Gentamicin (-20 mg/kg) was administered by constant intravenous infusion over a period of 3 h. With the low fluid infusion rate, furosemide (25 mg/kg intravenously) caused severe reduction in glomerular...

The purpose of this study was to determine the basic mechanism by which leukocyte-endothelial cell adhesion mediates platelet-activating factor (PAF)-induced increases in capillary fluid filtration rate. A modified Landis technique was used to observe fluid filtration from capillaries in the rat mesentery. Hypothetical mechanisms of increased filtration that were tested included 1) a direct act...

Under physiological conditions, interstitial fluid volume is tightly regulated by balancing microvascular filtration and lymphatic return to the central venous circulation. Even though microvascular filtration and lymphatic return are governed by conservation of mass, their interaction can result in exceedingly complex behavior. Without making simplifying assumptions, investigators must solve t...

objectives: different chelators may be used during root canal treatment, offering various advantages including lubricant effect inside the canal and smear layer removal. however, chelator residues in narrow root canals can lead to apical microleakage. the aim of this in-vitro study was to compare apical microleakage following the use of three root canal chelators via fluid filtration method in ...

Glomerular filtration in the kidney is a continuous process that acts in concert with tubular reabsorption to prevent derangements of body fluid composition. Filtration is regulated by systemic factors, but it is also controlled by an intrinsic mechanism based on the anatomical connection between the distal nephron and the glomerular arterioles. Facing the threat of urinary salt loss, this mech...

objectives: this study aimed to assess and compare the apical sealing ability of herofill® soft-core system and lateral condensation technique in fine curved canals using the fluid filtration method. materials and methods: forty human mesiobuccal root canals of mandibular first molars with 25° to 40° curvatures were instrumented to an apical size 30/0.04. roots were randomly assigned to two exp...