The functionalization of graphene remains an important challenge for numerous applications expected by this fascinating material. To keep advantageous properties of graphene after modification or functionalization of its structure, local approaches are a promising road. A novel technique is reported here that allows precise site-selective fluorination of graphene. The basic idea of this approac...

Fluorination has been widely used in chemical synthesis, but is rare in nature. The only known biological fluorination scope is represented by the fl pathway from Streptomyces cattleya that produces fluoroacetate (FAc) and 4-fluorothreonine (4-FT). Here we report the identification of a novel pathway for FAc and 4-FT biosynthesis from the actinomycetoma-causing pathogen Nocardia brasiliensis AT...

Fluorinated substrates like Teflon® (poly(tetrafluoroethylene); PTFE) are well known for their role in creating non-stick surfaces. We showed previously that even geckos, which can stick to most surfaces under a wide variety of conditions, slip on PTFE. Surprisingly, however, geckos can stick reasonably well to PTFE if it is wet. In an effort to explain this effect, we have turned our attention...

Fluorination is commonly exercised in compound property optimization. However, the influence of fluorination on hydrogen-bond (HB) properties of adjacent functional groups, as well as the HB-accepting capacity of fluorine itself, is still not completely understood. Although the formation of OH⋅⋅⋅F intramolecular HBs (IMHBs) has been established for conformationally restricted fluorohydrins, suc...

An operationally simple ipso fluorination of phenols with a new deoxyfluorination reagent is presented.

Although hydrously altered, CR chondrites are among the most primitive samples of the solar nebula because of no evidence for thermal or shock metamorphism [1], high presolar grain abundances [2], and perhaps because of their solar refrac-tory lithophile/Mg ratios [3]. Previous O-isotope measurements showed that CR chondrites form a mixing line of slope ~ 0.7 with a rather large scatter [4]. We...

The electrophilic fluorination of several (triphos)Pt-aryl(+) establishes the first example of aryl-F coupling from a Pt center.

Key words fluorination - dienes hypervalent iodine difunctionalization

The Prins reaction was investigated using BF₃.OEt₂ as a Lewis acid. It has been recently demonstrated, that if BF₃.OEt₂ is used in stoichiometric amounts then these reactions generate fluorinated products where the BF₃.OEt₂ contributes fluoride ion to quench the intermediate carbocations. In this study oxa- and aza-Prins reactions for the synthesis of 4-fluoro-pyrans and -piperidines were inves...

3-Fluoro-5-nitro-1-(pentafluorosulfanyl)benzene was prepared by three different ways: as a byproduct of direct fluorination of 1,2-bis(3-nitrophenyl)disulfane, by direct fluorination of 4-nitro-1-(pentafluorosulfanyl)benzene, and by fluorodenitration of 3,5-dinitro-1-(pentafluorosulfanyl)benzene. The title compound was subjected to a nucleophilic aromatic substitution of the fluorine atom with ...