Calmodulin has been purified from cell bodies of the green alga Chlamydomonas by Ca++-dependent affinity chromatography on fluphenazine-Sepharose 4B. Calmodulin from this primitive organism closely resembles that from bovine brain in a number of properties, including (a) binding to fluphenazine in a Ca++-dependent, reversible manner, (b) functioning as a heat-stable, Ca++-dependent activator of...

We describe a method for quantitative determination of fluphenazine in human plasma, based on gas chromatography of its trimethylsilyl derivative and the use of a structurally similar internal standard. We determined its concentrations in plasma of four patients who were receiving the drug intramuscularly as its decanoate, in doses ranging from 12.5 to 250 mg; the concentrations in the plasma o...

One hundred and twenty seven outpatient schizophrenics treated with fluphenazine decanoate (Modecate) depot therapy for a minimal period of 24 months were selected from all the psychiatric outpatient clinics in Singapore. Using a mirror image analysis in which patients act as their own controls, 105 patients showed a significant reduction of relapses requiring admissions from 139 before the ins...

Abstract—Male factor infertility due to endocrine disturbances such as abnormalities in prolactin levels are encountered in a significant proportion. This case control study was carried out to determine the effects of prolactin on the male reproductive tract, using 200 male white rats. The rats were maintained as the control group (G1), hypoprolactinaemic group (G2), 3 hyperprolactinaemic group...

• We studied if monoamines underly variation in animal personality, crickets. Our monoamine manipulation via Fluphenazine lowered both boldness and exploration. show that effects can be dose- behaviour-dependent. Latency to emerge from shelter used as a measure of Behavioural results depend on the drug used. Despite prevalence research interest its underlying mechanisms are not yet fully unders...