Focal adhesion disassembly is regulated by microtubules (MTs) through an unknown mechanism that involves dynamin. To test whether endocytosis may be involved, we interfered with the function of clathrin or its adaptors autosomal recessive hypercholesteremia (ARH) and Dab2 (Disabled-2) and found that both treatments prevented MT-induced focal adhesion disassembly. Surface labeling experiments sh...

Entrainment can be a useful method to identify reentry as a mechanism of ventricular tachycardia (VT). In this study, we evaluated the effect of gradually decreasing cycle lengths of overdrive pacing for stable VT induced in a canine model 1-3 h after coronary occlusion. Intact dogs underwent anterior descending coronary artery occlusion after instrumentation of the risk zone with 21 multipolar...

BACKGROUND To define the electrophysiological mechanism(s) of inducible and spontaneously occurring ventricular arrhythmias associated with nonischemic cardiomyopathy, 3-dimensional intraoperative mapping from 156 intramural sites was performed in 6 patients with idiopathic dilated cardiomyopathy undergoing cardiac transplantation. METHODS AND RESULTS Electrode density was sufficient to deter...

introduction: temporal lobe epilepsy (tle) is the most common and drug resistant epilepsy in adults. due to behavioral, morphologic and electrographic similarities, pilocarpine model of epilepsy best resembles tle. this study was aimed at determination of the changes in electroencephalogram (eeg) sub-bands amplitude during focal seizures in the pilocarpine model of epilepsy. analysis of these c...

Atrial tachycardia is an uncommon arrhythmia and may be focal or macroreentrant. This review concentrates on focal atrial tachycardia. Over the last decade there have been a number of advances in delineating the mechanism and anatomic locations of focal atrial tachycardia. The lack of efficacy of antiarrhythmic therapy and the advent of radiofrequency ablation have altered our primary approach ...

General approach These data are best analyzed by multiple regression, which can address all three hypotheses in one analysis. The first two hypotheses assert positive effects of the two independent variables separately, while the third hypotheses posits a positive (“reinforcement”) interaction between them; testing the latter therefore requires a multivariable analysis. The first two hypotheses...

In the paper [4] Montaldi proves a powerful transversality result which has a number of applications to the study of the generic geometry of submanifolds of Euclidean or projective space. As a typical application one can consider the contact of surfaces with spheres in Euclidean 3-space and describe the singularities that occur generically and, consequently, the local structure of the focal and...

We test whether S-wave/P-wave amplitude ratio data can improve the computed focal mechanisms of small earthquakes, using events from two southern California aftershock sequences. The observed S/P ratios are generally consistent with the expected mechanisms, implying that S/P ratios can in fact be useful in constraining the focal mechanisms of small events. However, we also find that noise in th...

In this paper, we propose a simple method for calibrating the effective focal length of central catadioptric cameras. This method uses the constraint that the projections of any three collinear space points on the viewing sphere should be on a great circle. We assume there are some inliers among the detected image points. If only three image points of a space line are well chosen, the constrain...

The derivation of the noise covariance of the ith projection view in Equation (5) is similar to the Appendix of Tilley et al. [22]; the difference is that our application is for DBT geometry in which the imaged volume is very close to the detector. As a result, we neglect the focal spot blur so the blurring operation in our study only includes the detector blur. For the directly measured projec...