In drug development, a common choice for the primary analysis is to assess mean changes via analysis of (co)variance with missing data imputed by carrying the last or baseline observations forward (LOCF, BOCF). These approaches assume that data are missing completely at random (MCAR). Multiple imputation (MI) and likelihood-based repeated measures (MMRM) are less restrictive as they assume data...

to inform healthcare professionals of a rare serious reaction leading to leg amputation following intramuscular injection of iron dextran and report comments for preventing such reactions.a case of leg amputation following intramuscular injection of iron dextran reported to iranian pharmacovigilance center was reviewed. patient and reaction data was collected by assessing the reported yellow ca...

The objective of this study was to evaluate whether the adverse effects of high dietary rice bran (RB) inclusion levels on the feed intake, performance, bone status and nitrogen (N) retention of broilers could be mitigated by wet feeding. Giving a completely randomized design experiment in 2 × 2 factorial arrangement, seventy two broiler chickens, managed in 24 floor pens received one of the tw...

This study aimed to evaluate the production and quality of açaí seedlings regarding presence absence controlled-release fertilization under different shading levels. The was conducted at experimental field Embrapa - Acre, using a completely randomized design in 4 x factorial arrangement. factors included four evaluation periods (60, 120, 180, 240 days after transplanting) environments (20%, 30%...

Twenty eight lactating buffaloes were used in a completely randomized design with 2×2 factorial arrangement of four experimental diets including low protein–low energy (LP-LE), low protein–high energy (LP-HE), high protein–low energy (HP-LE) and high protein–high energy (HP-HE). Results showed that the HP-HE diet recorded the highest digestibility coefficients of CP, EE, NFE, nutritive values, ...

the present study was carried out to investigate the effect of different levels of triticale with/ without enzyme cocktail (xylanase and β-glucanase) on performance of broiler chicks. five hundred day old male broiler chicks (ross 308), assigned to a factorial arrangement (5×2) with a completely randomized design with 5 replicates of 10 chicks each. the factors included 5 levels of triticale (0...