The endosomal sorting complexes required for transport (ESCRTs) constitute hetero-oligomeric machines that catalyze multiple topologically similar membrane-remodeling processes. Although ESCRT-III subunits polymerize into spirals, how individual ESCRT-III subunits are activated and assembled together into a membrane-deforming filament remains unknown. Here, we determine X-ray crystal structures...

This paper describes an error detection mechanism which helps in validation of dependency treebank annotation. Consistency in treebank annotation is a must for making data as errorfree as possible and for assuring the usefulness of treebank. This work is aimed at ensuring this consistency and to make the task of validation cost effective by detecting major errors induced during completely manua...

Vps4 is a member of AAA+ ATPase (adenosine triphosphatase associated with diverse cellular activities) that operates as an oligomer to disassemble ESCRT-III (endosomal sorting complex required for transport III) filaments, thereby catalyzing the final step in multiple ESCRT-dependent membrane remodeling events. We used electron cryo-microscopy to visualize oligomers of a hydrolysis-deficient Vp...

conclusions considering the high level of artificial colors found in the samples of this study, preventive measures are essential. results the results showed that several products did not meet the standards. fifty-six out of the 70 (80%) samples examined in the study, namely sunset yellow (60%), tartrazine (57.1%), quinoline yellow (44.28%), azorubine (28.57%), ponceau 4r (8.57%) and allura red...

This paper is a part of a wider research program concerning the assessment of quality at University. It was selected by the Department of University Policies (Ministry of Education, Science and Innovation) in an attempt to determine the causes and “reasons” underlying dropping school in our country. The Program includes three sub-projects concerning both academic and socio-professional success,...

Advanced live-cell imaging of the endosomal sorting complexes required for transport (ESCRT) and computational modeling have provided insights into the Vps4-dependent dynamic rearrangements of ESCRT-III filaments during membrane constriction and abscission.

Background: Listeria monocytogenes is a Gram-positive and facultative anaerobic food-borne bacterium which is capable of intra and extra cellular growth. L. monocytogenes usually can exist on different surfaces and instruments at production and processing sites of food products with animal origin. In Iran, the consumption of burger has increased recently, but its safety is still of great concer...

Background: Food and nutrition services in hospitals are one of the factors effecting patients’ satisfaction. Appropriate management and supervision in the nutrition sector is an essential factor in reducing the costs and gaining patient satisfaction. The optimal performance of the nutrition sector accelerates improvement and can be useful in their satisfaction. The purpose of this study was to...

Alveolar regenerative gene expression is unidentified partly because its onset, after a regenerative stimulus, is unknown. Toward addressing this void, we used a mouse model in which calorie restriction produces alveolar loss, and ad libitum access to food after calorie restriction induces alveolar regeneration. We selected four processes (cell replication, angiogenesis, extracellular matrix re...

Entrainment of anticipatory activity and wakefulness to nutrient availability is a poorly understood component of energy homeostasis. Restricted feeding (RF) paradigms with a periodicity of 24 h rapidly induce entrainment of rhythms anticipating food presentation that are independent of master clocks in the suprachiasmatic nucleus (SCN) but do require other hypothalamic structures. Here, we rep...