Tamoxifen, once the gold standard adjuvant endocrine therapy for early breast cancer, is being challenged by third-generation aromatase inhibitors (AIs) that have demonstrated improved disease-free survival in a variety of adjuvant settings for early breast cancer. Tamoxifen and AIs have different safety profiles, which should allow physicians to begin to individualize treatment based on a pati...

Appraising the success of information systems has long been a difficulty for management. Indeed, the definition of “success” is controversial as the term itself is multi-dimensional and can be assessed at various levels of the organisation using many differing criteria. However, the development of validated evaluation metrics is critical to future decision making for e-commerce success. This re...

The subcellular localization and physiological functions of biomolecules are closely related and thus it is crucial to precisely determine the distribution of different molecules inside the intracellular structures. This is frequently accomplished by fluorescence microscopy with well-characterized markers and posterior evaluation of the signal colocalization. Rigorous study of colocalization re...

Robin E Ferner, professor of clinical pharmacology , Dyfrig A Hughes, reader in pharmacoeconomics , Jeffrey K Aronson, reader in clinical pharmacology 3 1 West Midlands Centre For Adverse Drug Reactions, City Hospital, Birmingham B18 7QH, 2 Centre for Economics and Policy in Health, Institute of Medical and Social Care Research, Bangor University, Bangor LL57 1UT, 3 Department of Primary Health...