The cost-effectiveness and accuracy of a multidisciplinary design optimization (MDO) process is highly dependent on designers’ ability to flexibly formulate the optimization problem for specific challenges. Designers need to rapidly modify how object parameters are assigned to groupings of objects in the product model. Our research has developed a Reference-Based Optimization Method (RBOM) to e...

The Diagnostic and Statistical Manual of Mental Disorders, fifth edition, (DSM-5) Cultural Formulation Interview (CFI) is a systematic, semi-structured interview developed to guide clinicians on conducting a cultural assessment in routine mental health settings. An international field trial with 318 patients, 75 clinicians, and 86 family members in 6 countries found the core version of the CFI ...

The eye has protective barriers (ie, the conjunctival and corneal membranes) and defense mechanisms (ie, reflex tearing, blinking, lacrimal drainage) which present challenges to topical drug delivery. Topical ocular corticosteroids are commonly used in the treatment of anterior segment diseases and inflammation associated with ocular surgery, and manufacturers continually strive to improve thei...

A new formulation is presented for the modeling of immiscible compressible two-phase flow in porous media taking into account gravity, capillary effects and heterogeneity. The formulation is intended for the numerical simulation of multi-dimensional flows and is fully equivalent to the original equations, unlike the one introduced in Chavent and Jaffré (1986). The main feature of this formulati...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepar...

the purpose of this study was identification and applying ahp method in prioritization and comparison educational barriers and sustainable development on production of edible insects as diets from the viewpoint of selected groups. it was an applied research, research method was analytical, descriptive and statistical society was four groups of specialists, livestock and poultry producers, insec...