نتایج جستجو برای: fos

تعداد نتایج: 9380  

Journal: :Current Biology 1997
Michael E Geusz Colin Fletcher Gene D Block Martin Straume Neal G Copeland Nancy A Jenkins Steve A Kay Richard N Day

BACKGROUND The AP-1 family of transcription factors has been implicated in the control of the expression of many genes in response to environmental signals. Previous studies have provided temporal profiles for c-fos expression by taking measurements from many animals at several points in time, but these studies provide limited information about dynamic changes in expression. Here, we have devis...

Journal: :Molecular and cellular biology 1995
C Tsurumi N Ishida T Tamura A Kakizuka E Nishida E Okumura T Kishimoto M Inagaki K Okazaki N Sagata

c-Fos is associated with c-Jun to increase the transcription of a number of target genes and is a nuclear proto-oncoprotein with a very short half-life. This instability of c-Fos may be important in regulation of the normal cell cycle. Here we report a mechanism for degradation of c-Fos. Coexpression of c-Fos and c-Jun in HeLa cells caused marked increase in the instability of c-Fos, whereas v-...

Journal: :Molecular and cellular biology 2015
Nikoletta Szalóki Jan Wolfgang Krieger István Komáromi Katalin Tóth György Vámosi

The c-Fos and c-Jun transcription factors, members of the activator protein 1 (AP-1) complex, form heterodimers and bind to DNA via a basic leucine zipper and regulate the cell cycle, apoptosis, differentiation, etc. Purified c-Jun leucine zipper fragments could also form stable homodimers, whereas c-Fos leucine zipper homodimers were found to be much less stable in earlier in vitro studies. Th...

Journal: :NeuroSci 2022

For years, the biochemical processes that are triggered by harmful and non-harmful stimuli at central nervous system level have been extensively studied scientific community through numerous techniques animal models. example, one of these is use immediate expression genes, which a useful, accessible, reliable method for observing quantifying cell activation. It has shown both c-fos gene its pro...

Journal: :UNESA Journal of Chemistry 2022

Abstract. Fructooligosaccharides (FOS) are additives that often used and utilized in the food, pharmaceutical, chemical industries have functional value for health. Lactobacillus plantarum B1765 has been known to inulinase activity. This research aimed further explore potential of L.plantarum production FOS from lesser yam tuber inulin by looking at total growth lactic acid bacteria (LAB) degre...

Journal: :Journal of neurochemistry 2000
A M Gardier R Moratalla B Cuéllar M Sacerdote B Guibert H Lebrec A M Graybiel

To test for the relative contributions of the dopaminergic and serotoninergic systems in the striatum to the effects of d-fenfluramine, an indirect serotonin receptor agonist, we assessed the expression of Fos/Jun proteins induced by d-fenfluramine given alone or in the presence of dopaminergic or serotoninergic agents. To determine the neuronal targets of d-fenfluramine in the striatum, we ide...

Journal: :Blood 1999
S Okada T Fukuda K Inada T Tokuhisa

The proto-oncogene c-fos was transiently upregulated in primitive hematopoietic stem (Lin-Sca-1(+)) cells stimulated with stem cell factor, interleukin-3 (IL-3), and IL-6. To investigate a role of the c-fos in hematopoietic stem cells, we used bone marrow (BM) cells from transgenic mice carrying the c-fos gene under the control of the interferon-alpha/beta-inducible Mx-promoter (Mx-c-fos), and ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1990
D A Greenhalgh D J Welty A Player S H Yuspa

Previous studies have implicated the rasHa oncogene in the initiation of skin carcinogenesis and the fos oncogene in malignant progression of premalignant skin cell lines. To determine if these two oncogenes are sufficient to convert normal keratinocytes to cancer cells, freshly isolated mouse keratinocytes were coinfected with replication-defective (psi-2) v-rasHa and v-fos viruses in culture....

Journal: :The American journal of clinical nutrition 1996
C Molis B Flourié F Ouarne M F Gailing S Lartigue A Guibert F Bornet J P Galmiche

The fate of fructooligosaccharides (FOS) in the human gastrointestinal tract was evaluated in six healthy volunteers over an 11-d period. After an equilibration phase, 20.1 g FOS/d was given in three identical postprandial doses. Distal ileal output of FOS and their constituent components were determined by intestinal aspiration after a single meal, and the amounts of FOS excreted in stools and...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
V R Ramirez-Carrozzi T K Kerppola

Transcription initiation in eukaryotes is controlled by nucleoprotein complexes formed through cooperative interactions among multiple transcription regulatory proteins. These complexes may be assembled via stochastic collisions or defined pathways. We investigated the dynamics of Fos-Jun-NFAT1 complexes by using a multicolor fluorescence resonance energy transfer assay. Fos-Jun heterodimers ca...

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