The main objective of this paper was to manipulate the Nano Fibrous Scaffold "NFS" surface roughness to achieve a new transdermal drug release profile. To assess the intrinsic mechanical properties of Nylon 6 or polycaprolactam, such as its proper resiliency, it was considered as the matrix. Cetirizine was used as a drug model and was loaded (1% w/v) to polymer solution (30%w/v) before spinning...

The main objective of this paper was to manipulate the Nano Fibrous Scaffold "NFS" surface roughness to achieve a new transdermal drug release profile. To assess the intrinsic mechanical properties of Nylon 6 or polycaprolactam, such as its proper resiliency, it was considered as the matrix. Cetirizine was used as a drug model and was loaded (1% w/v) to polymer solution (30%w/v) before spinning...

The aim of this study is to formulate a novel ophthalmic nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of acyclovir (ACV). In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

aim: to enhance the aqueous solubility of olanzapine by using the solid dispersion technique. solid dispersions of olanzapine were prepared by the dispersion method using using pgs and ssg as carriers. drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

This present investigation deals with the development and optimization of polymeric nanoparticle systems loaded with 3,5,3'-triiodothyroacetic acid (Triac). A 2(11-6) fractional factorial design and another 2(2) factorial design were used to study the contrasts on particle size distribution, morphology, surface charge, drug content, entrapment efficiency, and in vitro drug release profiles. The...

the aim of this study is to formulate a novel ophthalmic nanosuspension (ons), an alternative carrier system to traditional colloidal carriers for controlled release (cr) of acyclovir (acv). in the present study, ons is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...

Little is known about the fate of the lipolytic products produced by the action of lipoprotein lipase (LPL) on circulating triglyceride-rich lipoproteins in humans. We studied eight lean, healthy male subjects after an overnight fast. Subjects received infusions of lipid emulsions containing triolein labeled with (3)H on both the glycerol backbone and the fatty acid portion of the molecule; (14...

microspheres formulated from poly (d,l-lactic-co-glycolide) (plga), a biodegradable polymer, have been extensively evaluated as a drug delivery system. in this study, the preparation, characterization and drug release properties of the plga microspheres were evaluated. simvastatin (sim)-loaded plga microspheres were prepared by oil-in-water emulsion/solvent evaporation method. the microspheres ...