Palmitate-1-(14)C was injected intravenously into unanesthetized, fasted rats. Disappearance of tracer from plasma free fatty acids was studied. A large component of free fatty acid (FFA) recycling was directly demonstrated by reinjection experiments. The latter studies also indicated the existence of an unidentified, rapidly turning over polar lipid in plasma which was synthesized from palmita...

Previous studies have shown that the free fatty acids (FFA) of blood plasma are renewed much more rapidly than the other plasma lipids (1-3). It has been calculated that, if oxidized, they could satisfy the requirements of oxidative metabolism in the postabsorptive state in man at rest (3). Measurements of arteriovenous (A-V) differences have shown that sufficient FFA are taken up by the heart ...

The myocardium is able to utilize both carbohydrates and noncarbohydrates for the performance of its work (1). Extraction of an individual substrate is usually determined by its arterial level. Thus, after a carbohydrate meal the heart derives much of its energy from the metabolism of carbohydrates; however, in the fasting state myocardial energy production is dependent upon noncarbohydrates, p...

Previous studies on normal and hypopituitary adults have demonstrated that administration of human growth hormone (HGH) is associated with changes in blood sugar (BS),'free fatty acids (FFA),"4 insulin like activity (ILA),' and plasma immunoreactive insulin (IRI).' The following investigation was carried out to study the acute effects of HGH on serum IRI, BS, and plasma FFA concentrations in no...

Lipolysis of triglycerides goes on constantly in adipose tissue producing glycerol and free fatty acids. The fatty acids can be activated and reesterified. Glycerol, on the other hand, is not metabolized to any significant extent (1-3). Glycerokinase, the enzyme that catalyzes the formation of a-glycerophosphate from glycerol and adenosine triphosphate, is apparently absent and glycerol is not ...

HOLLENBERG, C. H., AND A. ANGEL. Relation of fatty acid structure to release and esterijication of free fatty acids. Am. J. Physiol. 205(5): 909-912. I g63.-After incubation of rat adipose tissue with corticotrophin in buffer-albumin, the composition of the free fatty acids (FFA) in the tissue and in the medium was determined; the medium contained proportionately more myristic, palmitoleic, lin...

SCHIMMEL, RICHARD J., AND H. MAURICE GOODMAN. &Z'$~UX of free fatty acids from adipose tissue. Am. J. Physiol. 221(l) : 118-122. 197 1 .-Segments of rat epididymal adipose tissue were preincubated in Krebs-Ringer bicarbonate buffer for 30 min in the presence of epinephrine. The release of free fatty acids (FFA) formed during the preincubation period into albumin-containing media was measured du...

Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associate...

AIMS To develop a method to assess the relative binding of fatty acid ethyl esters (FAEE) and free fatty acids (FFA) to albumin, and to determine if binding affinity is related to fatty acid chain length and or degree of saturation. METHODS Radiolabelled ethyl-[14C] oleate bound to albumin was challenged with various ratios of FFA to FAEE. The displacement of ethyl-[14C] oleate by FFA was vis...

Lipolysis of triglycerides goes on constantly in adipose tissue producing glycerol and free fatty acids. The fatty acids can be activated and reesterified. Glycerol, on the other hand, is not metabolized to any significant extent (1-3). Glycerokinase, the enzyme that catalyzes the formation of a-glycerophosphate from glycerol and adenosine triphosphate, is apparently absent and glycerol is not ...