The development of new ROMP-derived silica-immobilized heterocyclic phosphate reagents and their application in purification-free protocols is reported. Grafting of norbornenyl norbornenyl-functionalized (Nb-tagged) silica particles with functionalized Nb-tagged heterocyclic phosphate monomers efficiently yield high-load, hybrid silica-immobilized oligomeric heterobenzyl phosphates (Si-OHBP) an...

We report a room-temperature photoinitiated polymerization-induced self-assembly (photo-PISA) of 2hydroxypropyl methacrylate (HPMA) in the presence of silica nanoparticles using a poly(ethylene glycol) methyl ether (mPEG) macromolecular chain transfer agent (macro-CTA). Hybrid vesicles loaded with silica nanoparticles were obtained by this one-pot approach. The solids content of the polymer ves...

This research describes application of a mesoporous nanostructured material based on basic ionic liquid anchored to silica, i.e. nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride {nano-[DMSPDE][Cl]}, as a highly effective and heterogeneous nanocatalyst for the production of 2-amino-4H-chromenes. The one-pot multi-component ...

An epidemiological investigation was carried out to determine the relationship between silicosis in hardrock miners in Ontario and cumulative exposure to silica (free crystalline silica--alpha quartz) dust. This second report describes a side-by-side air-sampling program used to derive a konimeter/gravimetric silica conversion curve. A total of 2,360 filter samples and 90,000 konimeter samples ...

Sol–gel chemistry is an efficient tool to control the morphology and reactivity of solids. Drying is the crucial step due to the capillary forces exerted during the classic ambient drying process, which induces the collapse of the wet gel porosity. The use of N, N-dimethylformamide (DMF), a newly found DCCA were found to be effective in the sol–gel synthesis of crack-free silica gel monolith fr...

Cisplatin is used to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application in many types of cancer including breast. Cisplatin was attached to silica nanoparticles using aminopropyltriethoxy silane as a linker molecule and characterized in terms of size, shape, as well as the dissolution of cisplatin from the silica surface. The prima...

We have created ellipsoidal or spherical morphologies of silica particles in a template-free scheme that involves controlling surface tension forces through selected volume ratios of a water/oil micellar system.

Silica is a toxicant that can stimulate cells to produce various cellular products such as free radicals, cytokines, and growth factors. Silica and its induced substances may induce apoptosis to regulate the evolution of silica-induced inflammation and fibrosis. To examine this hypothesis, groups of Wistar male rats were intratracheally instilled with different doses of Min-U-Sil 5 silica (Sili...