the goal of this study was to prepare and characterize alginate microspheres as an antigen delivery system and adjuvant for immunization against leishmaniasis. microspheres encapsulated with autoclaved leishmania major (alm) and quillaja saponin (qs) were prepared by an emulsification technique and characterized for size, encapsulation efficiency and release profile of encapsulates. selection o...

conclusions purified lps can be considered as a safe adjuvant and can be used as a component in prophylactic and therapeutic vaccines targeting infectious disease, cancer and allergies. results biochemical analysis data and sds-page profile showed that the chemical nature of s19 lps is different from rb51 lps. both s and r-lps induce an immune response. t-cell immune response induced by both s ...

abstract        background and objective: aluminum salts are among the most common useful additive compounds in preparation of human and animal vaccines. aluminum phosphate and aluminum hydroxide are two additives that show good immunoadjuvant effects with many antigens. aluminum-containing vaccines lead to a better and longer immune response compared to adjuvant-lacking vaccines. the chromogen...

introduction:mediastinum contains different vital structures that are located in the anterior and middle or posterior compartments. various types of mediastinal masses or tumors can be seen in the mediastinum. materials and methods:this case series study was performed on 95 patients who had referred to mashhad university of medical sciences between 1990 and 2010 were reviewed. the inclusion cri...

in the present study the effect of the locally produced genetic adjuvant of ginea pig specific cpg-motif-containing oligodeoxynucleotide (cpg-odn) in an inactivated fmd virus vaccine was evaluated. boosting the ginea pigs with fmd vaccine along with cpg-odn adjuvant produced relatively higher ratio (5-fold) of fmdv-specific igg2a / igg1 than those vaccinated in the absence of cpg-odn. the neutr...

introduction: an effective vaccine against hcv infection is not available. the non-structural protein 3 (ns3) of the virus as an important immunogenic candidate has been utilized in various modules. nanostructured polymers have been recently used for efficient vaccine and drug delivery. the aim of the current study was the synthesis of rns3-g2 conjugate and preliminary evaluation of its immunog...

background: nanoparticles have been considered as promising tools because of their high applicability. recently, nanoparticles have been evaluated for their ability to increase the immune responses as adjuvants. silver-nanoparticles (agnps) have shown promising results in enhancing th-2 immune responses and to produce potent neutralizing antibodies. neutralizing antibodies are considered as the...

compared to other methods of vaccine production, (e.g. culture flask and bioreactor system), the roller culture method for producing rabies vaccine is simpler, and the equipment easier to install and maintain, and also in the event of contamination of one roller, the entire batch need not be discarded. this system provides a much larger surface area than the culture flask, and also ensures a mu...

cholera toxin b subunit (ctxb) is a homopantameric, nontoxic subunit of cholera toxin that is responsible for its binding to the cell and has been known as a mucosal adjuvant for vaccines that could increase homoral and mocusal immunity response. in this work, the ctxb gene was fused to the stxb gene from shigella dysenteriae type i a vaccine antigen candidate against this pathogen, by a nonfur...

adjutants' ability in enhancing the performance of herbicides is a major priority in adjuvant research. to identify an appropriate adjuvant for pinoxaden and clodinafop propargyl herbicides against littleseed canarygrass (phalaris minor retz.), common wild oat (avena fatua l.) and ryegrass (lolium temulentum l.), three separate experiments were conducted under greenhouse conditions. in all...