In a fault tolerant control (FTC) system, a parameter varying FTC law is reconfigured based on fault parameters estimated by fault detection and isolation (FDI) modules. FDI modules require some time to detect fault occurrences in aero-vehicle dynamics. This paper illustrates analysis of a FTC system based on estimated fault parameter transient behavior which may include false fault detections ...

Study Finds Antiretroviral Drugs May Prevent HIV Infection A study involving monkeys found that the use of 2 antiretroviral drugs, emtricitabine (FTC) and tenofovir, prevented transmission of a primate version of HIV (Berman J. Voice of America. February 5, 2008). Lead researcher Walid Heneine of the CDC and colleagues injected macaques with single daily doses of FTC and then exposed them once ...

Emtricitabine (FTC) plus tenofovir alafenamide (TAF) has demonstrated efficacy and safety for pre-exposure prophylaxis (PrEP) to prevent HIV-1 infection. We measured the plasma PK of FTC, (TFV), TAF in a steady-state pharmacokinetic (PK) study bictegravir/FTC/TAF HIV-1-infected patients. Furthermore, validated liquid chromatography-tandem mass spectrometry was used measure intracellular TFV-dip...

BACKGROUND The HIV integrase strand transfer inhibitor elvitegravir (EVG) has been co-formulated with the CYP3A4 inhibitor cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) into a once-daily, single tablet. We compared EVG/COBI/FTC/TDF with a ritonavir-boosted (RTV) protease inhibitor regimen of atazanavir (ATV)/RTV+FTC/TDF as initial therapy for HIV-1 infection. ...

INTRODUCTION Highly active antiretroviral therapy (HAART) has allowed many HIV-infected patients to enjoy longer survival and a better quality of life. We performed an economic analysis to estimate the cost-effectiveness of HAART regimens in Italy for managing HIV-naïve infected patients with a viral load below 100,000 copies/mL. PATIENTS AND METHODS The population considered in the model con...

The fixed-dose combination (FDC) elvitegravir/cobicistat/emtricitabine/tenofovir (EVG/c/FTC/TDF) is a once-daily, single-tablet regimen containing an integrase strand transfer inhibitor and a pharmacoenhancer (cobicistat) associated with two nucleos(t)ide reverse transcriptase inhibitors. It is approved as the preferred regimen and as the first-line combined antiretroviral therapy in treatment-...

Fault tolerant control FTC is the branch of control theory, dealing with the control of systems that become faulty during their operating life. Following the systems classification, as linear and nonlinear models, FTC can be classified in two different groups, linear FTC LFTC dealing with linear models, and the one of interest to us in this paper, nonlinear FTC NFTC , which deals with nonlinear...

A new solid-phase extraction (SPE) method has been developed and validated on a liquid chromatography (LC) coupled with a mass spectrometer for the determination of plasma concentrations of tenofovir (TNF) and emtricitabine (FTC) in HIV infected patients. Chromatographic separation was achieved with a gradient (acetonitrile and water with formic acid 0.05%) on an Atlantis 4.6 mm x 150 mm, rever...

Although model-based fault tolerant control (FTC) has become prevalent in various engineering fields, its application to air-conditioning systems is limited due to the lack of controloriented models to characterize the phase change of refrigerant in the vapor compression cycle. The emergence of moving boundary method (MBM) illuminates a promising way for FTC design. In this paper, we exploit a ...

In this article, a new design method for an adaptive fast finite-time controller (FTC) is proposed the stability (FTS) issue of class high-order stochastic nonlinear systems (HOSNSs) with unknown parameters. Using power integrator technology and Lyapunov function approach, state feedback derived to ensure FTS HOSNSs. The developed FTC equipped less settling time obtain better steady-state accur...