The present investigation gathers the results of characterization and scientific analysis a memories album with albumen prints from end 19th century, belonging to art collector Calouste Sarkis Gulbenkian. study has focused on different analytical techniques, such as optical microscopy (OM), energy dispersive X-ray micro-fluorescence (ED-XRF), Fourier transform infrared spectroscopy attenuated t...

BACKGROUND Lactic acid is a versatile chemical platform with many different industrial applications. Yeasts have been demonstrated as attractive alternative to natural lactic acid producers since they can grow at low pH, allowing the direct purification of the product in the desired acidic form. However, when very high concentrations of organic acids are reached, the major limitation for a viab...

We have developed a rapid method to screen large numbers of mutant plants for a broad range of cell wall phenotypes using Fourier transform infrared (FTIR) microspectroscopy of leaves. We established and validated a model that can discriminate between the leaves of wild-type and a previously defined set of cell-wall mutants of Arabidopsis. Exploratory principal component analysis indicated that...

Hypoxia is a common feature of solid tumours and is associated with poor prognosis, resistance to radio- and chemotherapy, and tumour aggressiveness. For predictive purposes as well as for improved therapeutic intervention, it is increasingly needed to have direct and specific diagnostic tools in order to measure the extent of, and changes in, tumour hypoxia. In this article, we have investigat...

Fourier transform infrared spectroscopy (FTIR) provides a rapid non-destructive molecular characterization of organic and inorganic material in geological samples. Combination qualitative semi-quantitative approaches are routinely used FTIR study kerogen coals. A diversity descriptors straightforward tools to characterize type, composition structure. However, only few these applied the chemical...

Valproic acid/sodium valproate (VPA), a drug primarily used for treatment of seizure disorders, is recognized as an efficient epigenetic agent, inducing inhibition histone deacetylases, promoting changes in the methylation status DNA and histones, affecting chromatin structure. In addition to these effects, molecular affinity VPA H1 has been proposed based on thermal denaturation, fluorescence ...