BACKGROUND Dermal skin substitutes have become a standard of care in burn treatment. OBJECTIVE To compare and assess wound contracture reduction and histologic incorporation into the wound, dermal substitutes were implanted into full-thickness skin wounds in nude mice. MATERIALS AND METHODS Thirty-seven mice received a full-thickness 2 x 2 cm dorsal skin wound, and were either implanted wit...

objective(s) the process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. systemic administration of l-arginine promotes wound healing but its global side effects are undesirable. to confine the action of l-arginine at the site of injury, we tested the effects of local administration of l-arginine on the healing of excision...

New skin substitutes for burn medicine or reconstructive surgery pose an important issue in plastic surgery. Matriderm® is a clinically approved three-dimensional bovine collagen-elastin matrix which is already used as a dermal substitute of full thickness burn wounds. The drawback of an avital matrix is the limited integration in full thickness skin defects, depending on the defect size. To fu...

Objective(s) The process of wound healing involves tightly integrated events including inflammation, granulation tissue formation and remodeling. Systemic administration of L-arginine promotes wound healing but its global side effects are undesirable. To confine the action of L-arginine at the site of injury, we tested the effects of local administration of L-arginine on the healing of excisio...

The use of autograft skin is essential in the treatment of full thickness burns and large cutaneous defects. Both autograft thickness and condition of the wound bed modulate aesthetic and functional outcomes. Thicker autografts contract less and maintain greater functionality as the scar matures. The presence of hypodermis can also positively affect the eventual appearance and functionality of ...

Full thickness skin loss in the lower extremity presents special difficulties to the surgeon and his patient. Soft tissue in juxtaposition to the wound is usually remarkably thin and poorly vascularized. Moreover, the base of the wound very often is exposed, dead, infected bone. These chronic, persistent, economically debilitative ulcerations, traumatic, vascular, metabolic, or infectious in or...

the microorganisms have been noted as the main cause of delayed wound healing.the most common pathogen causing the wound infections is staphylococcus aureus. silver nanoparticles (agnps) show ample antibacterial activities. in the present study, the effect of agnps on mouse wounds inoculated with s. aureus was investigated. sixty male mice (20 to 30 g) were anesthetized, full-thickness skin wou...

Objective-The aim of this study was to investigate the healing effects of Ag+- zeolite/gelatin nanocomposite on excisional wound healing in rat animal model. Design-Experimental study Animals-Eighteen male Sprague-Dawly rats weighing 200-220g Procedure- Ag+- zeolite/gelatin nanocomposite was fabricated by sol-...