PI3K/AKT/mTOR pathway is an established oncogenic driver in humans. Targeted biologic agents against components of this pathway have shown promising activity leading to the approval of the allosteric inhibitors of mTOR, everolimus, and temsirolimus for the treatment of advanced cancers of the kidney, breast, and pancreas. Despite the established and promising activity of this therapeutic strate...

OBJECTIVE The objective of this mini-review is to examine a subset of literature that demonstrates multiple interactions between mechanics and biology within the spine and propose how incorporation of these mechano-biologic interactions can be applied to improve the conceptual understanding of tissue tolerances. BACKGROUND Low back pain represents a major musculoskeletal problem in the workpl...

BACKGROUND Despite significant advancements in new treatment modalities for rheumatoid arthritis with biological therapies, foot complications remain a disabling and common feature of the disease. In this study the aim was to explore and describe the personal experiences of people with rheumatoid arthritis in receipt of biologic treatments in a bid to understand the impact of this form of medic...

Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target 'foreign' sequences present in the complementarity determining regions (CDRs). Humanization of the mAb sequence is one approach that has been used to render biologics less foreign to the human immune ...

abstract : the crown-root fracture is a common tooth injury which compromises the biological width and need proper endodontic and prosthodontic treatment to achieve acceptable clinical outcome. this case report describes clinical management of crown-root fracture in maxillary central incisors which was successfully treated by forceps eruption with 180˚ rotation to restore the biological width. ...

soft tissue-implant interface is an important anatomical feature contributing to the long-term success of dental implants. based on the available evidence, different factors may influence biological width around implants including the surgical technique, implant loading, implant surface properties, abutment materials, implant position, and width of the peri-implant mucosa. the purpose of the pr...

Visual analysis of biomolecules is a fundamental subject of basic and applied biologic research. In such fields as genetics, biochemistry, and molecular biology, visible fluorescent protein constructs provide researchers with a tool of enormous value that has facilitated the identification of key molecules involved in cellular function in tissue sections and in living cells. Recently, the succe...

Visual analysis of biomolecules is a fundamental subject of basic and applied biologic research. In such fields as genetics, biochemistry, and molecular biology, visible fluorescent protein constructs provide researchers with a tool of enormous value that has facilitated the identification of key molecules involved in cellular function in tissue sections and in living cells. Recently, the succe...

An adequate understanding of the relationship between periodontal tissues and restorative dentistry is paramount to ensure adequate form, function, esthetics, and comfort of the dentition. While most clinicians are aware of this important relationship, uncertainty remains regarding specific concepts such as the biologic width and indications and applications for surgical crown lengthening. This...

Abdominal wall hernias occur when tissue structure and function are lost at the load-bearing muscle, tendon, and fascial layer. The fundamental biologic mechanisms are primary fascial pathology or surgical wound failure. In both cases, cellular and extracellular molecular matrix defects occur. Primary abdominal wall hernias have been associated with extracellular matrix diseases. Incisional her...