Irritable bowel syndrome is the most common functional gastrointestinal disorder, affecting up to 9% individuals globally. Although etiology of this likely heterogenous, it presents with its hallmark symptoms abdominal pain and altered intestinal motility. Moreover, considered be a disorder gut-brain interaction, microbiome has often been implicated as central player in pathophysiology. Patient...

To understand the pathophysiology of anomalous pain in functional gastrointestinal disorders, we must increase our understanding of how the central nervous system processes visceral pain. Over the past decade, novel application of functional brain imaging and electrophysiological techniques has given us the opportunity to study these processes in humans, and this review summarizes the current b...

Acute dyspepsia is a common gastrointestinal problem in clinical practice. Sometimes, this disorder is usually mentioned as a functional disorder[1]. This disease is due to the poor dietary behavior and there is a scientific evidence that the gastric infection by Helicobacter pylori (H. pylori) is the cause of this medical disorder. Here, the authors report on the prevalence of H. pylori seropo...

As a group, functional gastrointestinal disorders are the most common gastrointestinal disorder seen by both generalists and specialists. These disorders can be frustrating to both patients and physicians as they are usually chronic in nature and difficult to treat. These disorders are associated with frequent healthcare visits, the scheduling of multiple, expensive diagnostic tests, and the us...

Objective: Irritable Bowel Syndrome (IBS) is a chronic, disabling, and functional disorder of the gastrointestinal tract in the absence of identifiable structural disorder. The present study aimed to investigate the relationship between sensory processing sensitivity and life style with perceived stress considering mediating role of duration of syndrome in patients with IBS using structural equ...

aim and background: it has since long been known that there is strong relation between   psychological status and functional gastrointestinal disorders (fgid). however, until recently, the nature of this putative relationship was unclear due to a lack of non-invasive methods to investigate the neurobiological mechanisms underlying this relationship.  functional brain imaging has provided a meth...

BACKGROUND/AIMS Many patients with functional gastrointestinal disorders (FGIDs) rank sensations of bloating and distension among their most debilitating symptoms. Previous studies that have examined intestinal gas volume (IGV) in patients with FGIDs have employed a variety of invasive and imaging techniques. These studies are limited by small numbers and have shown conflicting results. The aim...

OBJECTIVES Comparison of comorbidity and healthcare consumption in primary healthcare subjects with persistent functional gastrointestinal disorder (FGID) and a strictly gastrointestinal (GI) symptom-free group (SSF). METHODS A stratified sample (n=1428, 21-86 years) of subjects living in the Osthammar community, Sweden, was limited to half of the community and classified through the Abdomina...

Gastrointestinal complaints without obvious organic causes confirmed by clinical laboratory analyses, endoscopy or radiology are often referred to functional entities. Irritable bowel syndrome (IBS) is the most common functional disorder in the gut. Careful examination of these patients may reveal other diagnoses of defined etiologies, e.g., enteric neuropathy, microscopic colitis, and primary ...